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Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design
SIMPLE SUMMARY: Nuclear matrix metalloproteinases are emerging to have distinct functions in a number of pathological conditions and physiological processes. In this article, we review what progress has been made in this area of research and discuss their potential in being targeted for future thera...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765953/ https://www.ncbi.nlm.nih.gov/pubmed/33352765 http://dx.doi.org/10.3390/biology9120480 |
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author | Frolova, Anastasia S. Petushkova, Anastasiia I. Makarov, Vladimir A. Soond, Surinder M. Zamyatnin, Andrey A. |
author_facet | Frolova, Anastasia S. Petushkova, Anastasiia I. Makarov, Vladimir A. Soond, Surinder M. Zamyatnin, Andrey A. |
author_sort | Frolova, Anastasia S. |
collection | PubMed |
description | SIMPLE SUMMARY: Nuclear matrix metalloproteinases are emerging to have distinct functions in a number of pathological conditions and physiological processes. In this article, we review what progress has been made in this area of research and discuss their potential in being targeted for future therapeutic design. ABSTRACT: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are responsible for the degradation of a wide range of extracellular matrix proteins, which are involved in many cellular processes to ensure the normal development of tissues and organs. Overexpression of MMPs has been observed to facilitate cellular growth, migration, and metastasis of tumor cells during cancer progression. A growing number of these proteins are being found to exist in the nuclei of both healthy and tumor cells, thus highlighting their localization as having a genuine purpose in cellular homeostasis. The mechanism underlying nuclear transport and the effects of MMP nuclear translocation have not yet been fully elucidated. To date, nuclear MMPs appear to have a unique impact on cellular apoptosis and gene regulation, which can have effects on immune response and tumor progression, and thus present themselves as potential therapeutic targets in certain types of cancer or disease. Herein, we highlight and evaluate what progress has been made in this area of research, which clearly has some value as a specific and unique way of targeting the activity of nuclear matrix metalloproteinases within various cell types. |
format | Online Article Text |
id | pubmed-7765953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77659532020-12-28 Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design Frolova, Anastasia S. Petushkova, Anastasiia I. Makarov, Vladimir A. Soond, Surinder M. Zamyatnin, Andrey A. Biology (Basel) Review SIMPLE SUMMARY: Nuclear matrix metalloproteinases are emerging to have distinct functions in a number of pathological conditions and physiological processes. In this article, we review what progress has been made in this area of research and discuss their potential in being targeted for future therapeutic design. ABSTRACT: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are responsible for the degradation of a wide range of extracellular matrix proteins, which are involved in many cellular processes to ensure the normal development of tissues and organs. Overexpression of MMPs has been observed to facilitate cellular growth, migration, and metastasis of tumor cells during cancer progression. A growing number of these proteins are being found to exist in the nuclei of both healthy and tumor cells, thus highlighting their localization as having a genuine purpose in cellular homeostasis. The mechanism underlying nuclear transport and the effects of MMP nuclear translocation have not yet been fully elucidated. To date, nuclear MMPs appear to have a unique impact on cellular apoptosis and gene regulation, which can have effects on immune response and tumor progression, and thus present themselves as potential therapeutic targets in certain types of cancer or disease. Herein, we highlight and evaluate what progress has been made in this area of research, which clearly has some value as a specific and unique way of targeting the activity of nuclear matrix metalloproteinases within various cell types. MDPI 2020-12-19 /pmc/articles/PMC7765953/ /pubmed/33352765 http://dx.doi.org/10.3390/biology9120480 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Frolova, Anastasia S. Petushkova, Anastasiia I. Makarov, Vladimir A. Soond, Surinder M. Zamyatnin, Andrey A. Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design |
title | Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design |
title_full | Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design |
title_fullStr | Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design |
title_full_unstemmed | Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design |
title_short | Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design |
title_sort | unravelling the network of nuclear matrix metalloproteinases for targeted drug design |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765953/ https://www.ncbi.nlm.nih.gov/pubmed/33352765 http://dx.doi.org/10.3390/biology9120480 |
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