Circulating Insulin-Like Growth Factor I is Involved in the Effect of High Fat Diet on Peripheral Amyloid β Clearance

Obesity is a risk factor for Alzheimer’s disease (AD), but underlying mechanisms are not clear. We analyzed peripheral clearance of amyloid β (Aβ) in overweight mice because its systemic elimination may impact brain Aβ load, a major landmark of AD pathology. We also analyzed whether circulating insu...

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Detalles Bibliográficos
Autores principales: Herrero-Labrador, Raquel, Trueba-Saiz, Angel, Martinez-Rachadell, Laura, Fernandez de Sevilla, Mᵃ Estrella, Zegarra-Valdivia, Jonathan A., Pignatelli, Jaime, Diaz-Pacheco, Sonia, Fernandez, Ana M., Torres Aleman, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766006/
https://www.ncbi.nlm.nih.gov/pubmed/33352990
http://dx.doi.org/10.3390/ijms21249675

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