Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae

The bioactivity-guided purification of the culture broth of the shipworm endosymbiont Teredinibacter turnerae strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (1), and two previously described oxylipins (2–3). Turneroic acid (1) is an 18-carbon fatty acid decorated by a hydroxy group and...

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Autores principales: Lacerna, Noel M., Ramones, Cydee Marie V., Robes, Jose Miguel D., Picart, Myra Ruth D., Tun, Jortan O., Miller, Bailey W., Haygood, Margo G., Schmidt, Eric W., Salvador-Reyes, Lilibeth A., Concepcion, Gisela P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766104/
https://www.ncbi.nlm.nih.gov/pubmed/33419303
http://dx.doi.org/10.3390/md18120656
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author Lacerna, Noel M.
Ramones, Cydee Marie V.
Robes, Jose Miguel D.
Picart, Myra Ruth D.
Tun, Jortan O.
Miller, Bailey W.
Haygood, Margo G.
Schmidt, Eric W.
Salvador-Reyes, Lilibeth A.
Concepcion, Gisela P.
author_facet Lacerna, Noel M.
Ramones, Cydee Marie V.
Robes, Jose Miguel D.
Picart, Myra Ruth D.
Tun, Jortan O.
Miller, Bailey W.
Haygood, Margo G.
Schmidt, Eric W.
Salvador-Reyes, Lilibeth A.
Concepcion, Gisela P.
author_sort Lacerna, Noel M.
collection PubMed
description The bioactivity-guided purification of the culture broth of the shipworm endosymbiont Teredinibacter turnerae strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (1), and two previously described oxylipins (2–3). Turneroic acid (1) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds 1–3 inhibited bacterial biofilm formation in Staphylococcus epidermidis, while only 3 showed antimicrobial activity against planktonic S. epidermidis. Comparison of the bioactivity of 1–3 with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition.
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spelling pubmed-77661042020-12-28 Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae Lacerna, Noel M. Ramones, Cydee Marie V. Robes, Jose Miguel D. Picart, Myra Ruth D. Tun, Jortan O. Miller, Bailey W. Haygood, Margo G. Schmidt, Eric W. Salvador-Reyes, Lilibeth A. Concepcion, Gisela P. Mar Drugs Article The bioactivity-guided purification of the culture broth of the shipworm endosymbiont Teredinibacter turnerae strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (1), and two previously described oxylipins (2–3). Turneroic acid (1) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds 1–3 inhibited bacterial biofilm formation in Staphylococcus epidermidis, while only 3 showed antimicrobial activity against planktonic S. epidermidis. Comparison of the bioactivity of 1–3 with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition. MDPI 2020-12-20 /pmc/articles/PMC7766104/ /pubmed/33419303 http://dx.doi.org/10.3390/md18120656 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lacerna, Noel M.
Ramones, Cydee Marie V.
Robes, Jose Miguel D.
Picart, Myra Ruth D.
Tun, Jortan O.
Miller, Bailey W.
Haygood, Margo G.
Schmidt, Eric W.
Salvador-Reyes, Lilibeth A.
Concepcion, Gisela P.
Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae
title Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae
title_full Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae
title_fullStr Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae
title_full_unstemmed Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae
title_short Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae
title_sort inhibition of biofilm formation by modified oxylipins from the shipworm symbiont teredinibacter turnerae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766104/
https://www.ncbi.nlm.nih.gov/pubmed/33419303
http://dx.doi.org/10.3390/md18120656
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