N-Terminal Tagging with GFP Enhances Selectivity of Agitoxin 2 to Kv1.3-Channel Binding Site

Recently developed fluorescent protein-scorpion toxin chimeras (FP-Tx) show blocking activities for potassium voltage-gated channels of Kv1 family and retain almost fully pharmacological profiles of the parental peptide toxins (Kuzmenkov et al., Sci Rep. 2016, 6, 33314). Here we report on N-terminal...

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Detalles Bibliográficos
Autores principales: Nekrasova, Oksana V., Primak, Alexandra L., Ignatova, Anastasia A., Novoseletsky, Valery N., Geras’kina, Olga V., Kudryashova, Ksenia S., Yakimov, Sergey A., Kirpichnikov, Mikhail P., Arseniev, Alexander S., Feofanov, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766132/
https://www.ncbi.nlm.nih.gov/pubmed/33339256
http://dx.doi.org/10.3390/toxins12120802

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