Effects of Fe(2+)/Fe(3+) Binding to Human Frataxin and Its D122Y Variant, as Revealed by Site-Directed Spin Labeling (SDSL) EPR Complemented by Fluorescence and Circular Dichroism Spectroscopies

Frataxin is a highly conserved protein whose deficiency results in the neurodegenerative disease Friederich’s ataxia. Frataxin’s actual physiological function has been debated for a long time without reaching a general agreement; however, it is commonly accepted that the protein is involved in the b...

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Detalles Bibliográficos
Autores principales: Doni, Davide, Passerini, Leonardo, Audran, Gérard, Marque, Sylvain R. A., Schulz, Marvin, Santos, Javier, Costantini, Paola, Bortolus, Marco, Carbonera, Donatella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766144/
https://www.ncbi.nlm.nih.gov/pubmed/33348670
http://dx.doi.org/10.3390/ijms21249619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766144/
https://www.ncbi.nlm.nih.gov/pubmed/33348670
http://dx.doi.org/10.3390/ijms21249619

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