Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927

We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of Epicoccum nigrum. The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and inhibited the germinat...

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Autores principales: Lee, Alex J., Cadelis, Melissa M., Kim, Sang H., Swift, Simon, Copp, Brent R., Villas-Boas, Silas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766273/
https://www.ncbi.nlm.nih.gov/pubmed/33352899
http://dx.doi.org/10.3390/molecules25245997
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author Lee, Alex J.
Cadelis, Melissa M.
Kim, Sang H.
Swift, Simon
Copp, Brent R.
Villas-Boas, Silas G.
author_facet Lee, Alex J.
Cadelis, Melissa M.
Kim, Sang H.
Swift, Simon
Copp, Brent R.
Villas-Boas, Silas G.
author_sort Lee, Alex J.
collection PubMed
description We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of Epicoccum nigrum. The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and inhibited the germination of fungal spores. The chemical characterization of the exudate showed that the pigmented molecule presenting antifungal activity is the disalt of epipyrone A—a water-soluble polyene metabolite with a molecular mass of 612.29 and maximal UV–Vis absorbance at 428 nm. This antifungal compound showed excellent stability to different temperatures and neutral to alkaline pH.
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spelling pubmed-77662732020-12-28 Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927 Lee, Alex J. Cadelis, Melissa M. Kim, Sang H. Swift, Simon Copp, Brent R. Villas-Boas, Silas G. Molecules Article We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of Epicoccum nigrum. The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and inhibited the germination of fungal spores. The chemical characterization of the exudate showed that the pigmented molecule presenting antifungal activity is the disalt of epipyrone A—a water-soluble polyene metabolite with a molecular mass of 612.29 and maximal UV–Vis absorbance at 428 nm. This antifungal compound showed excellent stability to different temperatures and neutral to alkaline pH. MDPI 2020-12-18 /pmc/articles/PMC7766273/ /pubmed/33352899 http://dx.doi.org/10.3390/molecules25245997 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Alex J.
Cadelis, Melissa M.
Kim, Sang H.
Swift, Simon
Copp, Brent R.
Villas-Boas, Silas G.
Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927
title Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927
title_full Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927
title_fullStr Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927
title_full_unstemmed Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927
title_short Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927
title_sort epipyrone a, a broad-spectrum antifungal compound produced by epicoccum nigrum icmp 19927
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766273/
https://www.ncbi.nlm.nih.gov/pubmed/33352899
http://dx.doi.org/10.3390/molecules25245997
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