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Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents

Caffeine-containing, nutritionally fortified energy shots are consumed at high rates by adolescents, yet little is known about their metabolic impact. The purpose of this study was to examine the consequences of small format, caffeinated energy shots on glucose metabolism and gastrointestinal hormon...

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Autores principales: Shearer, Jane, Reimer, Raylene A., Hittel, Dustin S., Gault, Mackenzie A., Vogel, Hans J., Klein, Matthias S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766305/
https://www.ncbi.nlm.nih.gov/pubmed/33339359
http://dx.doi.org/10.3390/nu12123850
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author Shearer, Jane
Reimer, Raylene A.
Hittel, Dustin S.
Gault, Mackenzie A.
Vogel, Hans J.
Klein, Matthias S.
author_facet Shearer, Jane
Reimer, Raylene A.
Hittel, Dustin S.
Gault, Mackenzie A.
Vogel, Hans J.
Klein, Matthias S.
author_sort Shearer, Jane
collection PubMed
description Caffeine-containing, nutritionally fortified energy shots are consumed at high rates by adolescents, yet little is known about their metabolic impact. The purpose of this study was to examine the consequences of small format, caffeinated energy shots on glucose metabolism and gastrointestinal hormone secretion in adolescents. Twenty participants aged 13–19 years participated in a double-blind, randomized cross-over study consisting of two trials separated by 1–4 weeks. Participants consumed a volume-matched caffeinated energy shot (CAF, 5 mg/kg) or a decaffeinated energy shot (DECAF) followed by a 2 h oral glucose tolerance test. Blood samples were collected and area under the curve (AUC) calculated for glucose, insulin and gut and metabolic hormones. Consumption of CAF resulted in a 25% increase in glucose and a 26% increase in insulin area under the curve (AUC, p = 0.037; p < 0.0001) compared to DECAF. No impact on gut hormones was observed. To further characterize responses, individuals were classified as either slow or fast caffeine metabolizers based on an allele score. Glucose intolerance was greater in genetically fast vs. slow caffeine metabolizers and differences between groups were supported by distinct serum metabolomics separation. Consumption of caffeine-containing energy shots results in acute impaired glucoregulation in healthy adolescents as characterized by hyperinsulinemia following an oral glucose challenge.
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spelling pubmed-77663052020-12-28 Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents Shearer, Jane Reimer, Raylene A. Hittel, Dustin S. Gault, Mackenzie A. Vogel, Hans J. Klein, Matthias S. Nutrients Article Caffeine-containing, nutritionally fortified energy shots are consumed at high rates by adolescents, yet little is known about their metabolic impact. The purpose of this study was to examine the consequences of small format, caffeinated energy shots on glucose metabolism and gastrointestinal hormone secretion in adolescents. Twenty participants aged 13–19 years participated in a double-blind, randomized cross-over study consisting of two trials separated by 1–4 weeks. Participants consumed a volume-matched caffeinated energy shot (CAF, 5 mg/kg) or a decaffeinated energy shot (DECAF) followed by a 2 h oral glucose tolerance test. Blood samples were collected and area under the curve (AUC) calculated for glucose, insulin and gut and metabolic hormones. Consumption of CAF resulted in a 25% increase in glucose and a 26% increase in insulin area under the curve (AUC, p = 0.037; p < 0.0001) compared to DECAF. No impact on gut hormones was observed. To further characterize responses, individuals were classified as either slow or fast caffeine metabolizers based on an allele score. Glucose intolerance was greater in genetically fast vs. slow caffeine metabolizers and differences between groups were supported by distinct serum metabolomics separation. Consumption of caffeine-containing energy shots results in acute impaired glucoregulation in healthy adolescents as characterized by hyperinsulinemia following an oral glucose challenge. MDPI 2020-12-16 /pmc/articles/PMC7766305/ /pubmed/33339359 http://dx.doi.org/10.3390/nu12123850 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shearer, Jane
Reimer, Raylene A.
Hittel, Dustin S.
Gault, Mackenzie A.
Vogel, Hans J.
Klein, Matthias S.
Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents
title Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents
title_full Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents
title_fullStr Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents
title_full_unstemmed Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents
title_short Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents
title_sort caffeine-containing energy shots cause acute impaired glucoregulation in adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766305/
https://www.ncbi.nlm.nih.gov/pubmed/33339359
http://dx.doi.org/10.3390/nu12123850
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