Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced Gastrotoxicity

Despite the availability of the current drug arsenal for pain management, there is still a clinical need to identify new, more effective, and safer analgesics. Based on our earlier study, newly synthesized 1,3,4-oxadiazole derivatives of pyrrolo[3,4-d]pyridazinone, especially 10b and 13b, seem to be...

Descripción completa

Detalles Bibliográficos
Autores principales: Szandruk-Bender, Marta, Wiatrak, Benita, Szczukowski, Łukasz, Świątek, Piotr, Rutkowska, Maria, Dzimira, Stanisław, Merwid-Ląd, Anna, Danielewski, Maciej, Szeląg, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766312/
https://www.ncbi.nlm.nih.gov/pubmed/33353118
http://dx.doi.org/10.3390/ijms21249685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766312/
https://www.ncbi.nlm.nih.gov/pubmed/33353118
http://dx.doi.org/10.3390/ijms21249685

Ejemplares similares