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Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced Gastrotoxicity

Despite the availability of the current drug arsenal for pain management, there is still a clinical need to identify new, more effective, and safer analgesics. Based on our earlier study, newly synthesized 1,3,4-oxadiazole derivatives of pyrrolo[3,4-d]pyridazinone, especially 10b and 13b, seem to be...

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Detalles Bibliográficos
Autores principales:	Szandruk-Bender, Marta, Wiatrak, Benita, Szczukowski, Łukasz, Świątek, Piotr, Rutkowska, Maria, Dzimira, Stanisław, Merwid-Ląd, Anna, Danielewski, Maciej, Szeląg, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766312/ https://www.ncbi.nlm.nih.gov/pubmed/33353118 http://dx.doi.org/10.3390/ijms21249685

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