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Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis
Background: The pancreas can be the site of neoplasms of several histogenetic origins; in most cases, tumors derive from the exocrine component, and ductal adenocarcinoma certainly prevails over the others. This tumor displays remarkably aggressive behavior, and it is often diagnosed at a late stage...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766336/ https://www.ncbi.nlm.nih.gov/pubmed/33352898 http://dx.doi.org/10.3390/medicina56120708 |
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author | Arcovito, Giorgia Di Stefano, Iosè Boldrini, Laura Manassero, Francesca Durante, Jacopo Tognarelli, Alessio Faviana, Pinuccia |
author_facet | Arcovito, Giorgia Di Stefano, Iosè Boldrini, Laura Manassero, Francesca Durante, Jacopo Tognarelli, Alessio Faviana, Pinuccia |
author_sort | Arcovito, Giorgia |
collection | PubMed |
description | Background: The pancreas can be the site of neoplasms of several histogenetic origins; in most cases, tumors derive from the exocrine component, and ductal adenocarcinoma certainly prevails over the others. This tumor displays remarkably aggressive behavior, and it is often diagnosed at a late stage of disease. Case presentation: We discuss the rare case of a 76-year-old male with locally advanced pancreatic head adenocarcinoma who developed uncommon metastatic disease. The bladder constitutes a very rare site of metastases, mostly deriving from melanoma, gastric, lung and breast cancers. The bladder’s secondary involvement in pancreatic malignancies represents an extremely unusual occurrence, and there are very few cases described in the literature to date. Conclusions: The finding of pancreatic adenocarcinoma metastases leads to a poor prognosis, and patients who are diagnosed at this stage constitute 53% of cases, with a 5-year survival of 3%. Although rare, therefore, the diagnostic hypothesis of pancreatic ductal adenocarcinoma (DAC) metastases to the bladder must, in some cases, be considered, especially if accompanied by a clinical picture that may suggest it. |
format | Online Article Text |
id | pubmed-7766336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77663362020-12-28 Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis Arcovito, Giorgia Di Stefano, Iosè Boldrini, Laura Manassero, Francesca Durante, Jacopo Tognarelli, Alessio Faviana, Pinuccia Medicina (Kaunas) Case Report Background: The pancreas can be the site of neoplasms of several histogenetic origins; in most cases, tumors derive from the exocrine component, and ductal adenocarcinoma certainly prevails over the others. This tumor displays remarkably aggressive behavior, and it is often diagnosed at a late stage of disease. Case presentation: We discuss the rare case of a 76-year-old male with locally advanced pancreatic head adenocarcinoma who developed uncommon metastatic disease. The bladder constitutes a very rare site of metastases, mostly deriving from melanoma, gastric, lung and breast cancers. The bladder’s secondary involvement in pancreatic malignancies represents an extremely unusual occurrence, and there are very few cases described in the literature to date. Conclusions: The finding of pancreatic adenocarcinoma metastases leads to a poor prognosis, and patients who are diagnosed at this stage constitute 53% of cases, with a 5-year survival of 3%. Although rare, therefore, the diagnostic hypothesis of pancreatic ductal adenocarcinoma (DAC) metastases to the bladder must, in some cases, be considered, especially if accompanied by a clinical picture that may suggest it. MDPI 2020-12-18 /pmc/articles/PMC7766336/ /pubmed/33352898 http://dx.doi.org/10.3390/medicina56120708 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Arcovito, Giorgia Di Stefano, Iosè Boldrini, Laura Manassero, Francesca Durante, Jacopo Tognarelli, Alessio Faviana, Pinuccia Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis |
title | Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis |
title_full | Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis |
title_fullStr | Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis |
title_full_unstemmed | Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis |
title_short | Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis |
title_sort | unusual case of pancreatic adenocarcinoma with bladder metastasis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766336/ https://www.ncbi.nlm.nih.gov/pubmed/33352898 http://dx.doi.org/10.3390/medicina56120708 |
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