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Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis

Background: The pancreas can be the site of neoplasms of several histogenetic origins; in most cases, tumors derive from the exocrine component, and ductal adenocarcinoma certainly prevails over the others. This tumor displays remarkably aggressive behavior, and it is often diagnosed at a late stage...

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Autores principales: Arcovito, Giorgia, Di Stefano, Iosè, Boldrini, Laura, Manassero, Francesca, Durante, Jacopo, Tognarelli, Alessio, Faviana, Pinuccia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766336/
https://www.ncbi.nlm.nih.gov/pubmed/33352898
http://dx.doi.org/10.3390/medicina56120708
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author Arcovito, Giorgia
Di Stefano, Iosè
Boldrini, Laura
Manassero, Francesca
Durante, Jacopo
Tognarelli, Alessio
Faviana, Pinuccia
author_facet Arcovito, Giorgia
Di Stefano, Iosè
Boldrini, Laura
Manassero, Francesca
Durante, Jacopo
Tognarelli, Alessio
Faviana, Pinuccia
author_sort Arcovito, Giorgia
collection PubMed
description Background: The pancreas can be the site of neoplasms of several histogenetic origins; in most cases, tumors derive from the exocrine component, and ductal adenocarcinoma certainly prevails over the others. This tumor displays remarkably aggressive behavior, and it is often diagnosed at a late stage of disease. Case presentation: We discuss the rare case of a 76-year-old male with locally advanced pancreatic head adenocarcinoma who developed uncommon metastatic disease. The bladder constitutes a very rare site of metastases, mostly deriving from melanoma, gastric, lung and breast cancers. The bladder’s secondary involvement in pancreatic malignancies represents an extremely unusual occurrence, and there are very few cases described in the literature to date. Conclusions: The finding of pancreatic adenocarcinoma metastases leads to a poor prognosis, and patients who are diagnosed at this stage constitute 53% of cases, with a 5-year survival of 3%. Although rare, therefore, the diagnostic hypothesis of pancreatic ductal adenocarcinoma (DAC) metastases to the bladder must, in some cases, be considered, especially if accompanied by a clinical picture that may suggest it.
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spelling pubmed-77663362020-12-28 Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis Arcovito, Giorgia Di Stefano, Iosè Boldrini, Laura Manassero, Francesca Durante, Jacopo Tognarelli, Alessio Faviana, Pinuccia Medicina (Kaunas) Case Report Background: The pancreas can be the site of neoplasms of several histogenetic origins; in most cases, tumors derive from the exocrine component, and ductal adenocarcinoma certainly prevails over the others. This tumor displays remarkably aggressive behavior, and it is often diagnosed at a late stage of disease. Case presentation: We discuss the rare case of a 76-year-old male with locally advanced pancreatic head adenocarcinoma who developed uncommon metastatic disease. The bladder constitutes a very rare site of metastases, mostly deriving from melanoma, gastric, lung and breast cancers. The bladder’s secondary involvement in pancreatic malignancies represents an extremely unusual occurrence, and there are very few cases described in the literature to date. Conclusions: The finding of pancreatic adenocarcinoma metastases leads to a poor prognosis, and patients who are diagnosed at this stage constitute 53% of cases, with a 5-year survival of 3%. Although rare, therefore, the diagnostic hypothesis of pancreatic ductal adenocarcinoma (DAC) metastases to the bladder must, in some cases, be considered, especially if accompanied by a clinical picture that may suggest it. MDPI 2020-12-18 /pmc/articles/PMC7766336/ /pubmed/33352898 http://dx.doi.org/10.3390/medicina56120708 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Arcovito, Giorgia
Di Stefano, Iosè
Boldrini, Laura
Manassero, Francesca
Durante, Jacopo
Tognarelli, Alessio
Faviana, Pinuccia
Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis
title Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis
title_full Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis
title_fullStr Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis
title_full_unstemmed Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis
title_short Unusual Case of Pancreatic Adenocarcinoma with Bladder Metastasis
title_sort unusual case of pancreatic adenocarcinoma with bladder metastasis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766336/
https://www.ncbi.nlm.nih.gov/pubmed/33352898
http://dx.doi.org/10.3390/medicina56120708
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