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Glycoconjugation of Betulin Derivatives Using Copper-Catalyzed 1,3-Dipolar Azido-Alkyne Cycloaddition Reaction and a Preliminary Assay of Cytotoxicity of the Obtained Compounds

Pentacyclic lupane-type triterpenoids, such as betulin and its synthetic derivatives, display a broad spectrum of biological activity. However, one of the major drawbacks of these compounds as potential therapeutic agents is their high hydrophobicity and low bioavailability. On the other hand, the p...

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Detalles Bibliográficos
Autores principales:	Grymel, Mirosława, Pastuch-Gawołek, Gabriela, Lalik, Anna, Zawojak, Mateusz, Boczek, Seweryn, Krawczyk, Monika, Erfurt, Karol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766341/ https://www.ncbi.nlm.nih.gov/pubmed/33353244 http://dx.doi.org/10.3390/molecules25246019

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