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Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer
The lysyl oxidase (LOX) family members are secreted copper-dependent amine oxidases, comprised of five paralogues: LOX and LOX-like l-4 (LOXL1-4), which are characterized by catalytic activity contributing to the remodeling of the cross-linking of the structural extracellular matrix (ECM). ECM remod...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766343/ https://www.ncbi.nlm.nih.gov/pubmed/33371259 http://dx.doi.org/10.3390/ijms21249751 |
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author | Lin, Hung-Yu Li, Chia-Jung Yang, Ya-Ling Huang, Ying-Hsien Hsiau, Ya-Tze Chu, Pei-Yi |
author_facet | Lin, Hung-Yu Li, Chia-Jung Yang, Ya-Ling Huang, Ying-Hsien Hsiau, Ya-Tze Chu, Pei-Yi |
author_sort | Lin, Hung-Yu |
collection | PubMed |
description | The lysyl oxidase (LOX) family members are secreted copper-dependent amine oxidases, comprised of five paralogues: LOX and LOX-like l-4 (LOXL1-4), which are characterized by catalytic activity contributing to the remodeling of the cross-linking of the structural extracellular matrix (ECM). ECM remodeling plays a key role in the angiogenesis surrounding tumors, whereby a corrupt tumor microenvironment (TME) takes shape. Primary liver cancer includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), ranked as the seventh most common cancer globally, with limited therapeutic options for advanced stages. In recent years, a growing body of evidence has revealed the key roles of LOX family members in the pathogenesis of liver cancer and the shaping of TME, indicating their notable potential as therapeutic targets. We herein review the clinical value and novel biological roles of LOX family members in tumor progression and the TME of liver cancers. In addition, we highlight recent insights into their mechanisms and their potential involvement in the development of target therapy for liver cancer. |
format | Online Article Text |
id | pubmed-7766343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77663432020-12-28 Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer Lin, Hung-Yu Li, Chia-Jung Yang, Ya-Ling Huang, Ying-Hsien Hsiau, Ya-Tze Chu, Pei-Yi Int J Mol Sci Review The lysyl oxidase (LOX) family members are secreted copper-dependent amine oxidases, comprised of five paralogues: LOX and LOX-like l-4 (LOXL1-4), which are characterized by catalytic activity contributing to the remodeling of the cross-linking of the structural extracellular matrix (ECM). ECM remodeling plays a key role in the angiogenesis surrounding tumors, whereby a corrupt tumor microenvironment (TME) takes shape. Primary liver cancer includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), ranked as the seventh most common cancer globally, with limited therapeutic options for advanced stages. In recent years, a growing body of evidence has revealed the key roles of LOX family members in the pathogenesis of liver cancer and the shaping of TME, indicating their notable potential as therapeutic targets. We herein review the clinical value and novel biological roles of LOX family members in tumor progression and the TME of liver cancers. In addition, we highlight recent insights into their mechanisms and their potential involvement in the development of target therapy for liver cancer. MDPI 2020-12-21 /pmc/articles/PMC7766343/ /pubmed/33371259 http://dx.doi.org/10.3390/ijms21249751 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lin, Hung-Yu Li, Chia-Jung Yang, Ya-Ling Huang, Ying-Hsien Hsiau, Ya-Tze Chu, Pei-Yi Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer |
title | Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer |
title_full | Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer |
title_fullStr | Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer |
title_full_unstemmed | Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer |
title_short | Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer |
title_sort | roles of lysyl oxidase family members in the tumor microenvironment and progression of liver cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766343/ https://www.ncbi.nlm.nih.gov/pubmed/33371259 http://dx.doi.org/10.3390/ijms21249751 |
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