Computational Insights into Allosteric Conformational Modulation of P-Glycoprotein by Substrate and Inhibitor Binding

The ATP-binding cassette (ABC) transporter P-glycoprotein (P-gp) is a physiologically essential membrane protein that protects many tissues against xenobiotic molecules, but limits the access of chemotherapeutics into tumor cells, thus contributing to multidrug resistance. The atomic-level mechanism...

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Detalles Bibliográficos
Autores principales: Xing, Juan, Huang, Shuheng, Heng, Yu, Mei, Hu, Pan, Xianchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766389/
https://www.ncbi.nlm.nih.gov/pubmed/33353070
http://dx.doi.org/10.3390/molecules25246006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766389/
https://www.ncbi.nlm.nih.gov/pubmed/33353070
http://dx.doi.org/10.3390/molecules25246006

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