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A Solvent System Involved Fabricating Electrospun Polyurethane Nanofibers for Biomedical Applications

A novel Trichloromethane (TCM)/2,2,2-Trifluoroethanol (TFE) solvent system was developed for fabricating electrospun thermoplastic polyurethane (TPU) nanofibers. TPU solution stability made from this novel solvent system was improved compared to that from the traditional N, N-Dimethylformamide (DMF)...

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Detalles Bibliográficos
Autores principales: Li, Biyun, Liu, Yinhu, Wei, Shuo, Huang, Yuting, Yang, Shuwen, Xue, Ye, Xuan, Hongyun, Yuan, Huihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766510/
https://www.ncbi.nlm.nih.gov/pubmed/33353093
http://dx.doi.org/10.3390/polym12123038
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author Li, Biyun
Liu, Yinhu
Wei, Shuo
Huang, Yuting
Yang, Shuwen
Xue, Ye
Xuan, Hongyun
Yuan, Huihua
author_facet Li, Biyun
Liu, Yinhu
Wei, Shuo
Huang, Yuting
Yang, Shuwen
Xue, Ye
Xuan, Hongyun
Yuan, Huihua
author_sort Li, Biyun
collection PubMed
description A novel Trichloromethane (TCM)/2,2,2-Trifluoroethanol (TFE) solvent system was developed for fabricating electrospun thermoplastic polyurethane (TPU) nanofibers. TPU solution stability made from this novel solvent system was improved compared to that from the traditional N, N-Dimethylformamide (DMF)/Tetrahydrofuran (THF) solvent system. The minimum TPU solution concentration that can be electrospun was decreased to 0.5% w/v. The conductivity and viscosity of the TPU solution increased with the increasing ratio of TFE in the solvent system. The obtained electrospun TPU nanofibers fabricated from this novel solvent system showed smooth morphology and uniform diameter distribution. Mechanical strength of TPU nanofibers was improved using this new solvent system. Young’s modulus and tensile strength of the electrospun TPU nanofiber meshes first decreased and then increased, while the strain elongation ratio first increased and then decreased. The new solvent system significantly improves the fiber elongation ratio while maintaining the modulus and tensile strength. The chemical structure of the TPU was not affected by the TCM/TFE solvent system. Electrospun TPU nanofiber meshes prepared by using the TCM/TFE solvent system showed better cytocompatibility, which means the electrospun TPU fibrous scaffold has great potential in biomedical application.
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spelling pubmed-77665102020-12-28 A Solvent System Involved Fabricating Electrospun Polyurethane Nanofibers for Biomedical Applications Li, Biyun Liu, Yinhu Wei, Shuo Huang, Yuting Yang, Shuwen Xue, Ye Xuan, Hongyun Yuan, Huihua Polymers (Basel) Article A novel Trichloromethane (TCM)/2,2,2-Trifluoroethanol (TFE) solvent system was developed for fabricating electrospun thermoplastic polyurethane (TPU) nanofibers. TPU solution stability made from this novel solvent system was improved compared to that from the traditional N, N-Dimethylformamide (DMF)/Tetrahydrofuran (THF) solvent system. The minimum TPU solution concentration that can be electrospun was decreased to 0.5% w/v. The conductivity and viscosity of the TPU solution increased with the increasing ratio of TFE in the solvent system. The obtained electrospun TPU nanofibers fabricated from this novel solvent system showed smooth morphology and uniform diameter distribution. Mechanical strength of TPU nanofibers was improved using this new solvent system. Young’s modulus and tensile strength of the electrospun TPU nanofiber meshes first decreased and then increased, while the strain elongation ratio first increased and then decreased. The new solvent system significantly improves the fiber elongation ratio while maintaining the modulus and tensile strength. The chemical structure of the TPU was not affected by the TCM/TFE solvent system. Electrospun TPU nanofiber meshes prepared by using the TCM/TFE solvent system showed better cytocompatibility, which means the electrospun TPU fibrous scaffold has great potential in biomedical application. MDPI 2020-12-18 /pmc/articles/PMC7766510/ /pubmed/33353093 http://dx.doi.org/10.3390/polym12123038 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Biyun
Liu, Yinhu
Wei, Shuo
Huang, Yuting
Yang, Shuwen
Xue, Ye
Xuan, Hongyun
Yuan, Huihua
A Solvent System Involved Fabricating Electrospun Polyurethane Nanofibers for Biomedical Applications
title A Solvent System Involved Fabricating Electrospun Polyurethane Nanofibers for Biomedical Applications
title_full A Solvent System Involved Fabricating Electrospun Polyurethane Nanofibers for Biomedical Applications
title_fullStr A Solvent System Involved Fabricating Electrospun Polyurethane Nanofibers for Biomedical Applications
title_full_unstemmed A Solvent System Involved Fabricating Electrospun Polyurethane Nanofibers for Biomedical Applications
title_short A Solvent System Involved Fabricating Electrospun Polyurethane Nanofibers for Biomedical Applications
title_sort solvent system involved fabricating electrospun polyurethane nanofibers for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766510/
https://www.ncbi.nlm.nih.gov/pubmed/33353093
http://dx.doi.org/10.3390/polym12123038
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