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Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress

As daily lifestyle is closely associated with mental illnesses, diet-based preventive approaches are receiving attention. Supplementation with hop bitter acids such as iso-α-acids (IAA) and mature hop bitter acids (MHBA) improves mood states in healthy older adults. However, the underlying mechanism...

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Autores principales: Ano, Yasuhisa, Kitaoka, Shiho, Ohya, Rena, Kondo, Keiji, Furuyashiki, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766517/
https://www.ncbi.nlm.nih.gov/pubmed/33348553
http://dx.doi.org/10.3390/ijms21249612
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author Ano, Yasuhisa
Kitaoka, Shiho
Ohya, Rena
Kondo, Keiji
Furuyashiki, Tomoyuki
author_facet Ano, Yasuhisa
Kitaoka, Shiho
Ohya, Rena
Kondo, Keiji
Furuyashiki, Tomoyuki
author_sort Ano, Yasuhisa
collection PubMed
description As daily lifestyle is closely associated with mental illnesses, diet-based preventive approaches are receiving attention. Supplementation with hop bitter acids such as iso-α-acids (IAA) and mature hop bitter acids (MHBA) improves mood states in healthy older adults. However, the underlying mechanism remains unknown. Since acute oral consumption with IAA increases dopamine levels in hippocampus and improves memory impairment via vagal nerve activation, here we investigated the effects of chronic administration of hop bitter acids on the dopaminergic activity associated with emotional disturbance in a mouse model of repeated social defeat stress (R-SDS). Chronic administration of IAA and MHBA significantly increased dopaminergic activity based on the dopamine metabolite to dopamine ratio in the hippocampus and medial prefrontal cortex following R-SDS. Hippocampal dopaminergic activity was inversely correlated with the level of R-SDS-induced social avoidance with or without IAA administration. Therefore, chronic treatment with hop bitter acids enhances stress resilience-related hippocampal dopaminergic activity.
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spelling pubmed-77665172020-12-28 Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress Ano, Yasuhisa Kitaoka, Shiho Ohya, Rena Kondo, Keiji Furuyashiki, Tomoyuki Int J Mol Sci Article As daily lifestyle is closely associated with mental illnesses, diet-based preventive approaches are receiving attention. Supplementation with hop bitter acids such as iso-α-acids (IAA) and mature hop bitter acids (MHBA) improves mood states in healthy older adults. However, the underlying mechanism remains unknown. Since acute oral consumption with IAA increases dopamine levels in hippocampus and improves memory impairment via vagal nerve activation, here we investigated the effects of chronic administration of hop bitter acids on the dopaminergic activity associated with emotional disturbance in a mouse model of repeated social defeat stress (R-SDS). Chronic administration of IAA and MHBA significantly increased dopaminergic activity based on the dopamine metabolite to dopamine ratio in the hippocampus and medial prefrontal cortex following R-SDS. Hippocampal dopaminergic activity was inversely correlated with the level of R-SDS-induced social avoidance with or without IAA administration. Therefore, chronic treatment with hop bitter acids enhances stress resilience-related hippocampal dopaminergic activity. MDPI 2020-12-17 /pmc/articles/PMC7766517/ /pubmed/33348553 http://dx.doi.org/10.3390/ijms21249612 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ano, Yasuhisa
Kitaoka, Shiho
Ohya, Rena
Kondo, Keiji
Furuyashiki, Tomoyuki
Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress
title Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress
title_full Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress
title_fullStr Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress
title_full_unstemmed Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress
title_short Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress
title_sort hop bitter acids increase hippocampal dopaminergic activity in a mouse model of social defeat stress
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766517/
https://www.ncbi.nlm.nih.gov/pubmed/33348553
http://dx.doi.org/10.3390/ijms21249612
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