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Transferrin Receptors in Erythropoiesis

Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron-containing hemes. Erythropoiesis is the most iron-c...

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Detalles Bibliográficos
Autores principales: Richard, Cyrielle, Verdier, Frédérique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766611/
https://www.ncbi.nlm.nih.gov/pubmed/33352721
http://dx.doi.org/10.3390/ijms21249713
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author Richard, Cyrielle
Verdier, Frédérique
author_facet Richard, Cyrielle
Verdier, Frédérique
author_sort Richard, Cyrielle
collection PubMed
description Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron-containing hemes. Erythropoiesis is the most iron-consuming process to support hemoglobin production. Iron delivery is mediated via transferrin internalization by the endocytosis of transferrin receptor type 1 (TFR1), one of the most abundant membrane proteins of erythroblasts. A second transferrin receptor—TFR2—associates with the erythropoietin receptor and has been implicated in the regulation of erythropoiesis. In erythroblasts, both transferrin receptors adopt peculiarities such as an erythroid-specific regulation of TFR1 and a trafficking pathway reliant on TFR2 for iron. This review reports both trafficking and signaling functions of these receptors and reassesses the debated role of TFR2 in erythropoiesis in the light of recent findings. Potential therapeutic uses targeting the transferrin-TFR1 axis or TFR2 in hematological disorders are also discussed.
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spelling pubmed-77666112020-12-28 Transferrin Receptors in Erythropoiesis Richard, Cyrielle Verdier, Frédérique Int J Mol Sci Review Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron-containing hemes. Erythropoiesis is the most iron-consuming process to support hemoglobin production. Iron delivery is mediated via transferrin internalization by the endocytosis of transferrin receptor type 1 (TFR1), one of the most abundant membrane proteins of erythroblasts. A second transferrin receptor—TFR2—associates with the erythropoietin receptor and has been implicated in the regulation of erythropoiesis. In erythroblasts, both transferrin receptors adopt peculiarities such as an erythroid-specific regulation of TFR1 and a trafficking pathway reliant on TFR2 for iron. This review reports both trafficking and signaling functions of these receptors and reassesses the debated role of TFR2 in erythropoiesis in the light of recent findings. Potential therapeutic uses targeting the transferrin-TFR1 axis or TFR2 in hematological disorders are also discussed. MDPI 2020-12-19 /pmc/articles/PMC7766611/ /pubmed/33352721 http://dx.doi.org/10.3390/ijms21249713 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Richard, Cyrielle
Verdier, Frédérique
Transferrin Receptors in Erythropoiesis
title Transferrin Receptors in Erythropoiesis
title_full Transferrin Receptors in Erythropoiesis
title_fullStr Transferrin Receptors in Erythropoiesis
title_full_unstemmed Transferrin Receptors in Erythropoiesis
title_short Transferrin Receptors in Erythropoiesis
title_sort transferrin receptors in erythropoiesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766611/
https://www.ncbi.nlm.nih.gov/pubmed/33352721
http://dx.doi.org/10.3390/ijms21249713
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