Cargando…
Transferrin Receptors in Erythropoiesis
Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron-containing hemes. Erythropoiesis is the most iron-c...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766611/ https://www.ncbi.nlm.nih.gov/pubmed/33352721 http://dx.doi.org/10.3390/ijms21249713 |
_version_ | 1783628760080187392 |
---|---|
author | Richard, Cyrielle Verdier, Frédérique |
author_facet | Richard, Cyrielle Verdier, Frédérique |
author_sort | Richard, Cyrielle |
collection | PubMed |
description | Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron-containing hemes. Erythropoiesis is the most iron-consuming process to support hemoglobin production. Iron delivery is mediated via transferrin internalization by the endocytosis of transferrin receptor type 1 (TFR1), one of the most abundant membrane proteins of erythroblasts. A second transferrin receptor—TFR2—associates with the erythropoietin receptor and has been implicated in the regulation of erythropoiesis. In erythroblasts, both transferrin receptors adopt peculiarities such as an erythroid-specific regulation of TFR1 and a trafficking pathway reliant on TFR2 for iron. This review reports both trafficking and signaling functions of these receptors and reassesses the debated role of TFR2 in erythropoiesis in the light of recent findings. Potential therapeutic uses targeting the transferrin-TFR1 axis or TFR2 in hematological disorders are also discussed. |
format | Online Article Text |
id | pubmed-7766611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77666112020-12-28 Transferrin Receptors in Erythropoiesis Richard, Cyrielle Verdier, Frédérique Int J Mol Sci Review Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron-containing hemes. Erythropoiesis is the most iron-consuming process to support hemoglobin production. Iron delivery is mediated via transferrin internalization by the endocytosis of transferrin receptor type 1 (TFR1), one of the most abundant membrane proteins of erythroblasts. A second transferrin receptor—TFR2—associates with the erythropoietin receptor and has been implicated in the regulation of erythropoiesis. In erythroblasts, both transferrin receptors adopt peculiarities such as an erythroid-specific regulation of TFR1 and a trafficking pathway reliant on TFR2 for iron. This review reports both trafficking and signaling functions of these receptors and reassesses the debated role of TFR2 in erythropoiesis in the light of recent findings. Potential therapeutic uses targeting the transferrin-TFR1 axis or TFR2 in hematological disorders are also discussed. MDPI 2020-12-19 /pmc/articles/PMC7766611/ /pubmed/33352721 http://dx.doi.org/10.3390/ijms21249713 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Richard, Cyrielle Verdier, Frédérique Transferrin Receptors in Erythropoiesis |
title | Transferrin Receptors in Erythropoiesis |
title_full | Transferrin Receptors in Erythropoiesis |
title_fullStr | Transferrin Receptors in Erythropoiesis |
title_full_unstemmed | Transferrin Receptors in Erythropoiesis |
title_short | Transferrin Receptors in Erythropoiesis |
title_sort | transferrin receptors in erythropoiesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766611/ https://www.ncbi.nlm.nih.gov/pubmed/33352721 http://dx.doi.org/10.3390/ijms21249713 |
work_keys_str_mv | AT richardcyrielle transferrinreceptorsinerythropoiesis AT verdierfrederique transferrinreceptorsinerythropoiesis |