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Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity

Since August 2012, universal single-dose vaccination in children aged at least three years has been implemented in the Republic of Tuva, which was previously the region most affected by hepatitis A in Russia. The objective of this cross-sectional study was the assessment of the immunological and epi...

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Autores principales: Mikhailov, Mikhail I., Lopatukhina, Maria A., Asadi Mobarhan, Fedor A., Ilchenko, Lyudmila Yu., Kozhanova, Tatyana V., Isaeva, Olga V., Karlsen, Anastasiya A., Potemkin, Ilya A., Kichatova, Vera S., Saryglar, Anna A., Oorzhak, Natalia D., Kyuregyan, Karen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766627/
https://www.ncbi.nlm.nih.gov/pubmed/33419299
http://dx.doi.org/10.3390/vaccines8040780
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author Mikhailov, Mikhail I.
Lopatukhina, Maria A.
Asadi Mobarhan, Fedor A.
Ilchenko, Lyudmila Yu.
Kozhanova, Tatyana V.
Isaeva, Olga V.
Karlsen, Anastasiya A.
Potemkin, Ilya A.
Kichatova, Vera S.
Saryglar, Anna A.
Oorzhak, Natalia D.
Kyuregyan, Karen K.
author_facet Mikhailov, Mikhail I.
Lopatukhina, Maria A.
Asadi Mobarhan, Fedor A.
Ilchenko, Lyudmila Yu.
Kozhanova, Tatyana V.
Isaeva, Olga V.
Karlsen, Anastasiya A.
Potemkin, Ilya A.
Kichatova, Vera S.
Saryglar, Anna A.
Oorzhak, Natalia D.
Kyuregyan, Karen K.
author_sort Mikhailov, Mikhail I.
collection PubMed
description Since August 2012, universal single-dose vaccination in children aged at least three years has been implemented in the Republic of Tuva, which was previously the region most affected by hepatitis A in Russia. The objective of this cross-sectional study was the assessment of the immunological and epidemiological effectiveness of vaccination program five years following its implementation. In the pre-vaccination period, anti-HAV antibody detection rates in Tuva was 66.0% [95% CI: 56.3–74.6%] in children aged 10–14 years and reached a plateau (>95%) by age 20–29 years. Annual incidence rates in children under 18 years of age peaked at 450–860 per 100,000 in pre-vaccination years but dropped to 7.5 per 100,000 in this age group and to 3.2 per 100,000 in the total population one year after the start of vaccination. Since 2016, no cases of hepatitis A has been reported in Tuva. Serum anti-HAV antibodies were quantified in samples from healthy children following single-dose vaccination. Protective anti-HAV antibody concentrations (≥10 mIU/mL) were detected in 98.0% (95% CI: 96.2–99.0% (442/451)) of children tested one month after single-dose immunization, in 93.5% (95% CI: 91.0–95.4% (477/510)) and in 91.1% (95% CI: 88.2–93.4% (422/463)) of children one year and five years after single-dose immunization, respectively. Anti-HAV antibody geometric mean concentrations were similar in sera collected one month, one year, and five years following single-dose vaccination: 40.24 mIU/mL, 44.96 mIU/mL, and 57.73 mIU/mL, respectively (p > 0.05). These data confirm that single-dose vaccination is an effective method of bringing hepatitis A under control in a short period of time in a highly endemic region.
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spelling pubmed-77666272020-12-28 Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity Mikhailov, Mikhail I. Lopatukhina, Maria A. Asadi Mobarhan, Fedor A. Ilchenko, Lyudmila Yu. Kozhanova, Tatyana V. Isaeva, Olga V. Karlsen, Anastasiya A. Potemkin, Ilya A. Kichatova, Vera S. Saryglar, Anna A. Oorzhak, Natalia D. Kyuregyan, Karen K. Vaccines (Basel) Article Since August 2012, universal single-dose vaccination in children aged at least three years has been implemented in the Republic of Tuva, which was previously the region most affected by hepatitis A in Russia. The objective of this cross-sectional study was the assessment of the immunological and epidemiological effectiveness of vaccination program five years following its implementation. In the pre-vaccination period, anti-HAV antibody detection rates in Tuva was 66.0% [95% CI: 56.3–74.6%] in children aged 10–14 years and reached a plateau (>95%) by age 20–29 years. Annual incidence rates in children under 18 years of age peaked at 450–860 per 100,000 in pre-vaccination years but dropped to 7.5 per 100,000 in this age group and to 3.2 per 100,000 in the total population one year after the start of vaccination. Since 2016, no cases of hepatitis A has been reported in Tuva. Serum anti-HAV antibodies were quantified in samples from healthy children following single-dose vaccination. Protective anti-HAV antibody concentrations (≥10 mIU/mL) were detected in 98.0% (95% CI: 96.2–99.0% (442/451)) of children tested one month after single-dose immunization, in 93.5% (95% CI: 91.0–95.4% (477/510)) and in 91.1% (95% CI: 88.2–93.4% (422/463)) of children one year and five years after single-dose immunization, respectively. Anti-HAV antibody geometric mean concentrations were similar in sera collected one month, one year, and five years following single-dose vaccination: 40.24 mIU/mL, 44.96 mIU/mL, and 57.73 mIU/mL, respectively (p > 0.05). These data confirm that single-dose vaccination is an effective method of bringing hepatitis A under control in a short period of time in a highly endemic region. MDPI 2020-12-20 /pmc/articles/PMC7766627/ /pubmed/33419299 http://dx.doi.org/10.3390/vaccines8040780 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mikhailov, Mikhail I.
Lopatukhina, Maria A.
Asadi Mobarhan, Fedor A.
Ilchenko, Lyudmila Yu.
Kozhanova, Tatyana V.
Isaeva, Olga V.
Karlsen, Anastasiya A.
Potemkin, Ilya A.
Kichatova, Vera S.
Saryglar, Anna A.
Oorzhak, Natalia D.
Kyuregyan, Karen K.
Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity
title Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity
title_full Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity
title_fullStr Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity
title_full_unstemmed Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity
title_short Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity
title_sort universal single-dose vaccination against hepatitis a in children in a region of high endemicity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766627/
https://www.ncbi.nlm.nih.gov/pubmed/33419299
http://dx.doi.org/10.3390/vaccines8040780
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