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Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases

Skin is our biggest organ. It interfaces our body with its environment. It is an efficient barrier to control the loss of water, the regulation of temperature, and infections by skin-resident and environmental pathogens. The barrier function of the skin is played by the stratum corneum (SC). It is a...

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Autores principales: Jebbawi, Ranime, Fruchon, Séverine, Turrin, Cédric-Olivier, Blanzat, Muriel, Poupot, Rémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766653/
https://www.ncbi.nlm.nih.gov/pubmed/33348690
http://dx.doi.org/10.3390/pharmaceutics12121224
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author Jebbawi, Ranime
Fruchon, Séverine
Turrin, Cédric-Olivier
Blanzat, Muriel
Poupot, Rémy
author_facet Jebbawi, Ranime
Fruchon, Séverine
Turrin, Cédric-Olivier
Blanzat, Muriel
Poupot, Rémy
author_sort Jebbawi, Ranime
collection PubMed
description Skin is our biggest organ. It interfaces our body with its environment. It is an efficient barrier to control the loss of water, the regulation of temperature, and infections by skin-resident and environmental pathogens. The barrier function of the skin is played by the stratum corneum (SC). It is a lipid barrier associating corneocytes (the terminally differentiated keratinocytes) and multilamellar lipid bilayers. This intricate association constitutes a very cohesive system, fully adapted to its role. One consequence of this efficient organization is the virtual impossibility for active pharmaceutical ingredients (API) to cross the SC to reach the inner layers of the skin after topical deposition. There are several ways to help a drug to cross the SC. Physical methods and chemical enhancers of permeation are a possibility. These are invasive and irritating methods. Vectorization of the drugs through nanocarriers is another way to circumvent the SC. This mini-review focuses on supramolecular and macromolecular matrices designed and implemented for skin permeation, excluding vesicular nanocarriers. Examples highlight the entrapment of anti-inflammatory API to treat inflammatory disorders of the skin.
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spelling pubmed-77666532020-12-28 Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases Jebbawi, Ranime Fruchon, Séverine Turrin, Cédric-Olivier Blanzat, Muriel Poupot, Rémy Pharmaceutics Review Skin is our biggest organ. It interfaces our body with its environment. It is an efficient barrier to control the loss of water, the regulation of temperature, and infections by skin-resident and environmental pathogens. The barrier function of the skin is played by the stratum corneum (SC). It is a lipid barrier associating corneocytes (the terminally differentiated keratinocytes) and multilamellar lipid bilayers. This intricate association constitutes a very cohesive system, fully adapted to its role. One consequence of this efficient organization is the virtual impossibility for active pharmaceutical ingredients (API) to cross the SC to reach the inner layers of the skin after topical deposition. There are several ways to help a drug to cross the SC. Physical methods and chemical enhancers of permeation are a possibility. These are invasive and irritating methods. Vectorization of the drugs through nanocarriers is another way to circumvent the SC. This mini-review focuses on supramolecular and macromolecular matrices designed and implemented for skin permeation, excluding vesicular nanocarriers. Examples highlight the entrapment of anti-inflammatory API to treat inflammatory disorders of the skin. MDPI 2020-12-17 /pmc/articles/PMC7766653/ /pubmed/33348690 http://dx.doi.org/10.3390/pharmaceutics12121224 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jebbawi, Ranime
Fruchon, Séverine
Turrin, Cédric-Olivier
Blanzat, Muriel
Poupot, Rémy
Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases
title Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases
title_full Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases
title_fullStr Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases
title_full_unstemmed Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases
title_short Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases
title_sort supramolecular and macromolecular matrix nanocarriers for drug delivery in inflammation-associated skin diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766653/
https://www.ncbi.nlm.nih.gov/pubmed/33348690
http://dx.doi.org/10.3390/pharmaceutics12121224
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