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Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology
SF3B1 is a core component of the U2 spliceosome that is frequently mutated in cancer. We have previously shown that titrating the activity of SF3B1, using the inhibitor pladienolide B (PB), affects distinct steps of the heat shock response (HSR). Here, we identify other genes that are sensitive to d...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766730/ https://www.ncbi.nlm.nih.gov/pubmed/33348896 http://dx.doi.org/10.3390/ijms21249641 |