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Detection of White Matter Ultrastructural Changes for Amyotrophic Lateral Sclerosis Characterization: A Diagnostic Study from Dti-Derived Data

In amyotrophic lateral sclerosis (ALS), magnetic resonance imaging (MRI) allows investigation at the microstructural level, employing techniques able to reveal white matter changes. In the current study, a diffusion tensor imaging (DTI) analysis, with a collection of apparent diffusion coefficient (...

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Autores principales: De Marchi, Fabiola, Stecco, Alessandro, Falaschi, Zeno, Filippone, Francesco, Pasché, Alessio, Bebeti, Alen, Leigheb, Massimiliano, Cantello, Roberto, Mazzini, Letizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766961/
https://www.ncbi.nlm.nih.gov/pubmed/33339434
http://dx.doi.org/10.3390/brainsci10120996
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author De Marchi, Fabiola
Stecco, Alessandro
Falaschi, Zeno
Filippone, Francesco
Pasché, Alessio
Bebeti, Alen
Leigheb, Massimiliano
Cantello, Roberto
Mazzini, Letizia
author_facet De Marchi, Fabiola
Stecco, Alessandro
Falaschi, Zeno
Filippone, Francesco
Pasché, Alessio
Bebeti, Alen
Leigheb, Massimiliano
Cantello, Roberto
Mazzini, Letizia
author_sort De Marchi, Fabiola
collection PubMed
description In amyotrophic lateral sclerosis (ALS), magnetic resonance imaging (MRI) allows investigation at the microstructural level, employing techniques able to reveal white matter changes. In the current study, a diffusion tensor imaging (DTI) analysis, with a collection of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) indexes, was performed in ALS patients to correlate geno- and phenotype features with MRI data, to investigate an in-vivo correlation of different neuropathological patterns. All patients who underwent the MR-DTI analysis were retrospectively recruited. MRI scan was collected within three months from diagnosis. FA and ADC values were collected in corpus callosum (CC), corona radiata (CR), cerebral peduncle (CR), cerebellar peduncle (CbP) and corticospinal tract at posterior limb of internal capsule (CST). DTI analysis performed in the whole ALS cohort revealed significant FA reduction and ADC increase in all selected regions, as widespread changes. Moreover, we observed a higher value of FA in rCR in bulbar patients. A positive correlation between ALS Functional Rating Scale-Revised and FA in rCP was evident. In consideration of the non-invasiveness, the reliability and the easy reproducibility of the method, we believe that brain MRI with DTI analyses may represent a valid tool usable as a diagnostic marker in ALS.
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spelling pubmed-77669612020-12-28 Detection of White Matter Ultrastructural Changes for Amyotrophic Lateral Sclerosis Characterization: A Diagnostic Study from Dti-Derived Data De Marchi, Fabiola Stecco, Alessandro Falaschi, Zeno Filippone, Francesco Pasché, Alessio Bebeti, Alen Leigheb, Massimiliano Cantello, Roberto Mazzini, Letizia Brain Sci Article In amyotrophic lateral sclerosis (ALS), magnetic resonance imaging (MRI) allows investigation at the microstructural level, employing techniques able to reveal white matter changes. In the current study, a diffusion tensor imaging (DTI) analysis, with a collection of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) indexes, was performed in ALS patients to correlate geno- and phenotype features with MRI data, to investigate an in-vivo correlation of different neuropathological patterns. All patients who underwent the MR-DTI analysis were retrospectively recruited. MRI scan was collected within three months from diagnosis. FA and ADC values were collected in corpus callosum (CC), corona radiata (CR), cerebral peduncle (CR), cerebellar peduncle (CbP) and corticospinal tract at posterior limb of internal capsule (CST). DTI analysis performed in the whole ALS cohort revealed significant FA reduction and ADC increase in all selected regions, as widespread changes. Moreover, we observed a higher value of FA in rCR in bulbar patients. A positive correlation between ALS Functional Rating Scale-Revised and FA in rCP was evident. In consideration of the non-invasiveness, the reliability and the easy reproducibility of the method, we believe that brain MRI with DTI analyses may represent a valid tool usable as a diagnostic marker in ALS. MDPI 2020-12-16 /pmc/articles/PMC7766961/ /pubmed/33339434 http://dx.doi.org/10.3390/brainsci10120996 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Marchi, Fabiola
Stecco, Alessandro
Falaschi, Zeno
Filippone, Francesco
Pasché, Alessio
Bebeti, Alen
Leigheb, Massimiliano
Cantello, Roberto
Mazzini, Letizia
Detection of White Matter Ultrastructural Changes for Amyotrophic Lateral Sclerosis Characterization: A Diagnostic Study from Dti-Derived Data
title Detection of White Matter Ultrastructural Changes for Amyotrophic Lateral Sclerosis Characterization: A Diagnostic Study from Dti-Derived Data
title_full Detection of White Matter Ultrastructural Changes for Amyotrophic Lateral Sclerosis Characterization: A Diagnostic Study from Dti-Derived Data
title_fullStr Detection of White Matter Ultrastructural Changes for Amyotrophic Lateral Sclerosis Characterization: A Diagnostic Study from Dti-Derived Data
title_full_unstemmed Detection of White Matter Ultrastructural Changes for Amyotrophic Lateral Sclerosis Characterization: A Diagnostic Study from Dti-Derived Data
title_short Detection of White Matter Ultrastructural Changes for Amyotrophic Lateral Sclerosis Characterization: A Diagnostic Study from Dti-Derived Data
title_sort detection of white matter ultrastructural changes for amyotrophic lateral sclerosis characterization: a diagnostic study from dti-derived data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766961/
https://www.ncbi.nlm.nih.gov/pubmed/33339434
http://dx.doi.org/10.3390/brainsci10120996
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