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Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam

Low water solubility frequently compromises the therapeutic efficacy of drugs and other biologically active molecules. Here, we report on coacervate polysaccharide nanoparticles (CPNs) that can transport and release a model hydrophobic drug, piroxicam, to the cells in response to changes in temperat...

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Autores principales: Lachowicz, Dorota, Kaczyńska, Agnieszka, Bodzon-Kulakowska, Anna, Karewicz, Anna, Wirecka, Roma, Szuwarzyński, Michał, Zapotoczny, Szczepan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767055/
https://www.ncbi.nlm.nih.gov/pubmed/33352956
http://dx.doi.org/10.3390/ijms21249664
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author Lachowicz, Dorota
Kaczyńska, Agnieszka
Bodzon-Kulakowska, Anna
Karewicz, Anna
Wirecka, Roma
Szuwarzyński, Michał
Zapotoczny, Szczepan
author_facet Lachowicz, Dorota
Kaczyńska, Agnieszka
Bodzon-Kulakowska, Anna
Karewicz, Anna
Wirecka, Roma
Szuwarzyński, Michał
Zapotoczny, Szczepan
author_sort Lachowicz, Dorota
collection PubMed
description Low water solubility frequently compromises the therapeutic efficacy of drugs and other biologically active molecules. Here, we report on coacervate polysaccharide nanoparticles (CPNs) that can transport and release a model hydrophobic drug, piroxicam, to the cells in response to changes in temperature. The proposed, temperature-responsive drug delivery system is based on ionic derivatives of natural polysaccharides—curdlan and hydroxypropyl cellulose. Curdlan was modified with trimethylammonium groups, while the anionic derivative of hydroxypropyl cellulose was obtained by the introduction of styrenesulfonate groups. Thermally responsive nanoparticles of spherical shape and average hydrodynamic diameter in the range of 250–300 nm were spontaneously formed in water from the obtained ionic polysaccharides as a result of the coacervation process. Their morphology was visualized using SEM and AFM. The size and the surface charge of the obtained objects could be tailored by adjusting the polycation/polyanion ratio. Piroxicam (PIX) was effectively entrapped inside the nanoparticles. The release profile of the drug from the CPNs-PIX was found to be temperature-dependent in the range relevant for biomedical applications.
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spelling pubmed-77670552020-12-28 Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam Lachowicz, Dorota Kaczyńska, Agnieszka Bodzon-Kulakowska, Anna Karewicz, Anna Wirecka, Roma Szuwarzyński, Michał Zapotoczny, Szczepan Int J Mol Sci Article Low water solubility frequently compromises the therapeutic efficacy of drugs and other biologically active molecules. Here, we report on coacervate polysaccharide nanoparticles (CPNs) that can transport and release a model hydrophobic drug, piroxicam, to the cells in response to changes in temperature. The proposed, temperature-responsive drug delivery system is based on ionic derivatives of natural polysaccharides—curdlan and hydroxypropyl cellulose. Curdlan was modified with trimethylammonium groups, while the anionic derivative of hydroxypropyl cellulose was obtained by the introduction of styrenesulfonate groups. Thermally responsive nanoparticles of spherical shape and average hydrodynamic diameter in the range of 250–300 nm were spontaneously formed in water from the obtained ionic polysaccharides as a result of the coacervation process. Their morphology was visualized using SEM and AFM. The size and the surface charge of the obtained objects could be tailored by adjusting the polycation/polyanion ratio. Piroxicam (PIX) was effectively entrapped inside the nanoparticles. The release profile of the drug from the CPNs-PIX was found to be temperature-dependent in the range relevant for biomedical applications. MDPI 2020-12-18 /pmc/articles/PMC7767055/ /pubmed/33352956 http://dx.doi.org/10.3390/ijms21249664 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lachowicz, Dorota
Kaczyńska, Agnieszka
Bodzon-Kulakowska, Anna
Karewicz, Anna
Wirecka, Roma
Szuwarzyński, Michał
Zapotoczny, Szczepan
Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam
title Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam
title_full Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam
title_fullStr Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam
title_full_unstemmed Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam
title_short Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam
title_sort coacervate thermoresponsive polysaccharide nanoparticles as delivery system for piroxicam
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767055/
https://www.ncbi.nlm.nih.gov/pubmed/33352956
http://dx.doi.org/10.3390/ijms21249664
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