Cargando…

New Application of 1,2,4-Triazole Derivatives as Antitubercular Agents. Structure, In Vitro Screening and Docking Studies

A series of 1,2,4-triazole derivatives were synthesized and assigned as potential anti-tuberculosis substances. The molecular and crystal structures for the model compounds C1, C12, and C13 were determined using X-ray analysis. The X-ray investigation confirmed the synthesis pathway and the assumed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karczmarzyk, Zbigniew, Swatko-Ossor, Marta, Wysocki, Waldemar, Drozd, Monika, Ginalska, Grazyna, Pachuta-Stec, Anna, Pitucha, Monika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767103/ https://www.ncbi.nlm.nih.gov/pubmed/33352814 http://dx.doi.org/10.3390/molecules25246033

Ejemplares similares

Synthesis, In Vitro Screening and Docking Studies of New Thiosemicarbazide Derivatives as Antitubercular Agents
por: Pitucha, Monika, et al.
Publicado: (2019)

3-Benzyl-4-ethyl-1H-1,2,4-triazole-5(4H)-thione
por: Karczmarzyk, Zbigniew, et al.
Publicado: (2013)

Ethyl 2-(3-methyl-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-4-yl)acetate
por: Karczmarzyk, Zbigniew, et al.
Publicado: (2012)

Morphological Changes in the Overall Mycobacterium tuberculosisH(37)Ra Cell Shape and Cytoplasm Homogeneity due to Mutellina purpurea L. Essential Oil and Its Main Constituents
por: Sieniawska, Elwira, et al.
Publicado: (2015)

The Effect of Combining Natural Terpenes and Antituberculous Agents against Reference and Clinical Mycobacterium tuberculosis Strains
por: Sieniawska, Elwira, et al.
Publicado: (2018)

Quantification of Lipophilicity of 1,2,4-Triazoles Using Micellar Chromatography
por: Janicka, Małgorzata, et al.
Publicado: (2012)

Synthesis, antibacterial and antiproliferative potential of some new 1-pyridinecarbonyl-4-substituted thiosemicarbazide derivatives
por: Pitucha, Monika, et al.
Publicado: (2016)

Nigella damascena L. Essential Oil—A Valuable Source of β-Elemene for Antimicrobial Testing
por: Sieniawska, Elwira, et al.
Publicado: (2018)

Potential Anticancer Agents against Melanoma Cells Based on an As-Synthesized Thiosemicarbazide Derivative
por: Kozyra, Paweł, et al.
Publicado: (2022)

1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study
por: Branowska, Danuta, et al.
Publicado: (2020)

1,3-Dimethyl-5-methylsulfonyl-1H-pyrazolo[4,3-e][1,2,4]triazine
por: Mojzych, Mariusz, et al.
Publicado: (2010)

5,5′,6,6′-Tetramethyl-3,3′-bi-1,2,4-triazine
por: Wolińska, Ewa, et al.
Publicado: (2011)

Influence of Complexation of Thiosemicarbazone Derivatives with Cu (II) Ions on Their Antitumor Activity against Melanoma Cells
por: Pitucha, Monika, et al.
Publicado: (2021)

Synthesis and RP HPLC studies of biologically active semicarbazides and their cyclic analogues 1,2,4-triazol-3-ones
por: Pitucha, Monika, et al.
Publicado: (2012)

Synthesis, Characterization, Antitubercular Activity, and Molecular Docking Studies of Pyrazolylpyrazoline-Clubbed Triazole and Tetrazole Hybrids
por: Zala, Mayursinh, et al.
Publicado: (2023)

Synthesis of unsymmetrical disulfanes bearing 1,2,4-triazine scaffold and their in vitro screening towards anti-breast cancer activity
por: Branowska, Danuta, et al.
Publicado: (2018)

Synthesis, Spectral, Thermal and Biological Studies of 4-Cyclohexyl-3-(4-nitrophenyl)methyl-1,2,4-triazolin-5-thione and Its Copper(II) Coordination Compound, [CuCl(2)(H(2)O)(2)L(2)]
por: Czylkowska, Agnieszka, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Some Triazole Schiff’s Base Derivatives as Potential Antitubercular Agents
por: Sager, Asma A., et al.
Publicado: (2018)

1,2,4-Triazoles as Important Antibacterial Agents
por: Strzelecka, Małgorzata, et al.
Publicado: (2021)

Isolation and Evaluation of the Enantiospecific Antitubercular Activity of a Novel Triazole Compound
por: Shekar, Radha, et al.
Publicado: (2014)

1-(3-Chlorophenyl)-3-(1-p-tolylimidazolidin-2-ylidene)urea
por: Wysocki, Waldemar, et al.
Publicado: (2008)

2-(5,6-Diphenyl-1,2,4-triazin-3-yl)aniline
por: Mojzych, Mariusz, et al.
Publicado: (2012)

Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivatives
por: Xia, Meng-Yu, et al.
Publicado: (2023)

5,6,7,8-Tetrahydroquinolin-8-one
por: Lipińska, Teodozja M., et al.
Publicado: (2011)

Exploration of Piperidinols as Potential Antitubercular Agents
por: Abuhammad, Areej, et al.
Publicado: (2014)

5,6,7,8-Tetrahydroquinoline 1-oxide hemihydrate
por: Karczmarzyk, Zbigniew, et al.
Publicado: (2010)

Synthesis, 3D-QSAR and Molecular Docking Study of Nopol-Based 1,2,4-Triazole-Thioether Compounds as Potential Antifungal Agents
por: Wang, Xiu, et al.
Publicado: (2021)

Antibacterial Activity of Fluorobenzoylthiosemicarbazides and Their Cyclic Analogues with 1,2,4-Triazole Scaffold
por: Kosikowska, Urszula, et al.
Publicado: (2020)

6-(2-Chlorobenzyl)-1-(4-chlorophenyl)-7-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one
por: Wysocki, Waldemar, et al.
Publicado: (2010)

Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies
por: Rateb, Heba S., et al.
Publicado: (2016)

Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents
por: Revathi, Rajappan, et al.
Publicado: (2015)

1,2-Bis[1-(3-methylsulfanyl-1,2,4-triazin-5-yl)ethylidene]diazane
por: Mojzych, Mariusz, et al.
Publicado: (2009)

Synthesis, Structural Characterization, and Biological Activity of New Pyrazolo[4,3-e][1,2,4]triazine Acyclonucleosides
por: Mojzych, Mariusz, et al.
Publicado: (2020)

N-{2-[(4S)-4-tert-Butyl-4,5-dihydro-1,3-oxazol-2-yl]phenyl}-5,6-diphenyl-1,2,4-triazin-3-amine
por: Karczmarzyk, Zbigniew, et al.
Publicado: (2011)

New Conjugates of Quinoxaline as Potent Antitubercular and Antibacterial Agents
por: Peraman, Ramalingam, et al.
Publicado: (2016)

Synthesis and Screening of New [1,3,4]Oxadiazole, [1,2,4]Triazole, and [1,2,4]Triazolo[4,3-b][1,2,4]triazole Derivatives as Potential Antitumor Agents on the Colon Carcinoma Cell Line (HCT-116)
por: Abdelrehim, El-sayed M.
Publicado: (2021)

Highly Luminescent 4H-1,2,4-Triazole Derivatives: Synthesis, Molecular Structure and Photophysical Properties
por: Olesiejuk, Monika, et al.
Publicado: (2020)

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
por: Kumari, Mukesh, et al.
Publicado: (2021)

Design, synthesis and evaluation of novel 1,2,4-triazole derivatives as promising anticancer agents
por: Emami, Leila, et al.
Publicado: (2022)

New Potential Agents for Malignant Melanoma Treatment—Most Recent Studies 2020–2022
por: Kozyra, Paweł, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0rcqa02mkl2mfjg4judrt6bdbt