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Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy

This retrospective, nationwide, matched cohort study investigated the temporal relationship of central serous chorioretinopathy (CSCR) following topical ophthalmic corticosteroid (TOC) use. Using the Longitudinal Health Insurance Database 2000 (LHID2000), we collected patients diagnosed with CSCR be...

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Autores principales: Chang, Yuh-Shin, Weng, Shih-Feng, Wang, Jhi-Joung, Jan, Ren-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767174/
https://www.ncbi.nlm.nih.gov/pubmed/33348672
http://dx.doi.org/10.3390/ijerph17249455
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author Chang, Yuh-Shin
Weng, Shih-Feng
Wang, Jhi-Joung
Jan, Ren-Long
author_facet Chang, Yuh-Shin
Weng, Shih-Feng
Wang, Jhi-Joung
Jan, Ren-Long
author_sort Chang, Yuh-Shin
collection PubMed
description This retrospective, nationwide, matched cohort study investigated the temporal relationship of central serous chorioretinopathy (CSCR) following topical ophthalmic corticosteroid (TOC) use. Using the Longitudinal Health Insurance Database 2000 (LHID2000), we collected patients diagnosed with CSCR between January 2001 and December 2010 (n  =  2921) and a control group (n  =  17,526). Information for each patient was collected and tracked from the index date until December 2011. TOC users were classified based on (i) the date of the last prescription before diagnosis: current users (≤30 days) and former users (31–182 days and ≥183 days) and (ii) the prescription refill intervals: persistent users (interval ≤90 days) and non-persistent users (interval >90 days). The odds ratio (OR) was estimated from multivariate conditional logistic regression after adjusting for relevant confounders. After adjusting for age, sex, geographic region, index date, previously known comorbidities, the date of last TOC prescription before diagnosis, or prescription refilling intervals, the results revealed that patients were likely to have developed CSCR while using TOCs currently (OR = 30.42, 95% CI = 25.95–35.66, p < 0.001) and persistently (OR = 7.30, 95% CI = 6.13–8.69, p < 0.001) as compared to the controls. Our results indicate that current or persistent TOCs use increases the risk of CSCR. Thus, patients requiring TOCs should be advised of this risk, particularly in current or persistent use conditions.
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spelling pubmed-77671742020-12-28 Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy Chang, Yuh-Shin Weng, Shih-Feng Wang, Jhi-Joung Jan, Ren-Long Int J Environ Res Public Health Article This retrospective, nationwide, matched cohort study investigated the temporal relationship of central serous chorioretinopathy (CSCR) following topical ophthalmic corticosteroid (TOC) use. Using the Longitudinal Health Insurance Database 2000 (LHID2000), we collected patients diagnosed with CSCR between January 2001 and December 2010 (n  =  2921) and a control group (n  =  17,526). Information for each patient was collected and tracked from the index date until December 2011. TOC users were classified based on (i) the date of the last prescription before diagnosis: current users (≤30 days) and former users (31–182 days and ≥183 days) and (ii) the prescription refill intervals: persistent users (interval ≤90 days) and non-persistent users (interval >90 days). The odds ratio (OR) was estimated from multivariate conditional logistic regression after adjusting for relevant confounders. After adjusting for age, sex, geographic region, index date, previously known comorbidities, the date of last TOC prescription before diagnosis, or prescription refilling intervals, the results revealed that patients were likely to have developed CSCR while using TOCs currently (OR = 30.42, 95% CI = 25.95–35.66, p < 0.001) and persistently (OR = 7.30, 95% CI = 6.13–8.69, p < 0.001) as compared to the controls. Our results indicate that current or persistent TOCs use increases the risk of CSCR. Thus, patients requiring TOCs should be advised of this risk, particularly in current or persistent use conditions. MDPI 2020-12-17 2020-12 /pmc/articles/PMC7767174/ /pubmed/33348672 http://dx.doi.org/10.3390/ijerph17249455 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Yuh-Shin
Weng, Shih-Feng
Wang, Jhi-Joung
Jan, Ren-Long
Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy
title Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy
title_full Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy
title_fullStr Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy
title_full_unstemmed Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy
title_short Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy
title_sort temporal association between topical ophthalmic corticosteroid and the risk of central serous chorioretinopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767174/
https://www.ncbi.nlm.nih.gov/pubmed/33348672
http://dx.doi.org/10.3390/ijerph17249455
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