Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling

Red tides involving Karenia brevis expose humans to brevetoxins (PbTxs). Oral exposition triggers neurotoxic shellfish poisoning, whereas inhalation induces a respiratory syndrome and sensory disturbances. No curative treatment is available and the pathophysiology is not fully elucidated. Protease-a...

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Detalles Bibliográficos
Autores principales: Pierre, Ophélie, Fouchard, Maxime, Buscaglia, Paul, Le Goux, Nelig, Leschiera, Raphaël, Mignen, Olivier, Fluhr, Joachim W., Misery, Laurent, Le Garrec, Raphaële
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767211/
https://www.ncbi.nlm.nih.gov/pubmed/33348659
http://dx.doi.org/10.3390/cells9122704

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