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Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28

An appreciation for the complex interactions between the NF-κB transcription factor and the Lin28 RNA binding protein/let-7 microRNA pathways has grown substantially over the past decade. Both the NF-κB and Lin28/let-7 pathways are master regulators impacting cell survival, growth and proliferation,...

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Autores principales: Mills, William T., Nassar, Noor N., Ravindra, Deepa, Li, Xinbei, Meffert, Mollie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767241/
https://www.ncbi.nlm.nih.gov/pubmed/33348917
http://dx.doi.org/10.3390/cells9122710
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author Mills, William T.
Nassar, Noor N.
Ravindra, Deepa
Li, Xinbei
Meffert, Mollie K.
author_facet Mills, William T.
Nassar, Noor N.
Ravindra, Deepa
Li, Xinbei
Meffert, Mollie K.
author_sort Mills, William T.
collection PubMed
description An appreciation for the complex interactions between the NF-κB transcription factor and the Lin28 RNA binding protein/let-7 microRNA pathways has grown substantially over the past decade. Both the NF-κB and Lin28/let-7 pathways are master regulators impacting cell survival, growth and proliferation, and an understanding of how interfaces between these pathways participate in governing pluripotency, progenitor differentiation, and neuroplastic responses remains an emerging area of research. In this review, we provide a concise summary of the respective pathways and focus on the function of signaling interactions at both the transcriptional and post-transcriptional levels. Regulatory loops capable of providing both reinforcing and extinguishing feedback have been described. We highlight convergent findings in disparate biological systems and indicate future directions for investigation.
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spelling pubmed-77672412020-12-28 Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28 Mills, William T. Nassar, Noor N. Ravindra, Deepa Li, Xinbei Meffert, Mollie K. Cells Review An appreciation for the complex interactions between the NF-κB transcription factor and the Lin28 RNA binding protein/let-7 microRNA pathways has grown substantially over the past decade. Both the NF-κB and Lin28/let-7 pathways are master regulators impacting cell survival, growth and proliferation, and an understanding of how interfaces between these pathways participate in governing pluripotency, progenitor differentiation, and neuroplastic responses remains an emerging area of research. In this review, we provide a concise summary of the respective pathways and focus on the function of signaling interactions at both the transcriptional and post-transcriptional levels. Regulatory loops capable of providing both reinforcing and extinguishing feedback have been described. We highlight convergent findings in disparate biological systems and indicate future directions for investigation. MDPI 2020-12-17 /pmc/articles/PMC7767241/ /pubmed/33348917 http://dx.doi.org/10.3390/cells9122710 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mills, William T.
Nassar, Noor N.
Ravindra, Deepa
Li, Xinbei
Meffert, Mollie K.
Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28
title Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28
title_full Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28
title_fullStr Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28
title_full_unstemmed Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28
title_short Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28
title_sort multi-level regulatory interactions between nf-κb and the pluripotency factor lin28
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767241/
https://www.ncbi.nlm.nih.gov/pubmed/33348917
http://dx.doi.org/10.3390/cells9122710
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