Cargando…

Adipocyte-Derived Leptin Promotes PAI-1-Mediated Breast Cancer Metastasis in a STAT3/miR-34a Dependent Manner

SIMPLE SUMMARY: Although adipocytes affect the metastatic behavior of cancer cells, the underlying molecular mechanisms remain largely elusive. Thereby, we sought to screen for the signaling pathways responsible for adipocyte-induced motility of breast cancer cells by employing a breast cancer cell/...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Si-Jing, Wei, Xiao-Hui, Zhan, Xiao-Man, He, Jin-Yong, Zeng, Yu-Qi, Tian, Xue-Mei, Yuan, Sheng-Tao, Sun, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767398/ https://www.ncbi.nlm.nih.gov/pubmed/33371368 http://dx.doi.org/10.3390/cancers12123864

Ejemplares similares

Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling
por: Wei, Xiaohui, et al.
Publicado: (2019)

miR-34a targets PAI-1 to regulate urinary microalbumin and renal function in hypertensive mice
por: Liu, Ruitao, et al.
Publicado: (2020)

miR-34a regulates adipogenesis in porcine intramuscular adipocytes by targeting ACSL4
por: Wang, Wenwen, et al.
Publicado: (2020)

Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression
por: He, Jin-Yong, et al.
Publicado: (2018)

miR-34a exerts as a key regulator in the dedifferentiation of osteosarcoma via PAI-1–Sox2 axis
por: Zhang, Yu, et al.
Publicado: (2018)

Hyperglycaemia-induced reciprocal changes in miR-30c and PAI-1 expression in platelets
por: Luo, Mao, et al.
Publicado: (2016)

MiR-34c suppresses tumor growth and metastasis in nasopharyngeal carcinoma by targeting MET
por: Li, Y-Q, et al.
Publicado: (2015)

Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes
por: Ge, X, et al.
Publicado: (2017)

Metformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis
por: Suwei, Dong, et al.
Publicado: (2022)

Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway
por: Wang, Jie, et al.
Publicado: (2019)

Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer
por: Avtanski, Dimiter B., et al.
Publicado: (2015)

Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop
por: Li, Huihui, et al.
Publicado: (2015)

PAI‐1, a target gene of miR‐143, regulates invasion and metastasis by upregulating MMP‐13 expression of human osteosarcoma
por: Hirahata, Mio, et al.
Publicado: (2016)

Leptin Induces Proadipogenic and Proinflammatory Signaling in Adipocytes
por: Palhinha, Lohanna, et al.
Publicado: (2019)

Quantitative Proteomic Analysis of Gene Regulation by miR-34a and miR-34c
por: Ebner, Olivia A., et al.
Publicado: (2014)

Los viejos de mi país
por: Fernández, Juan Carlos 1939-
Publicado: (1982)

Small molecule targeting miR-34a for cancer therapy
por: Xiao, Zhangang, et al.
Publicado: (2015)

MicroRNA miR-874-3p inhibits osteoporosis by targeting leptin (LEP)
por: Mei, Ling, et al.
Publicado: (2021)

Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms
por: Chim, Chor Sang, et al.
Publicado: (2011)

The lncRNA NEAT1 promotes the epithelial-mesenchymal transition and metastasis of osteosarcoma cells by sponging miR-483 to upregulate STAT3 expression
por: Chen, Yan, et al.
Publicado: (2021)

Melatonin alleviates vascular calcification and ageing through exosomal miR‐204/miR‐211 cluster in a paracrine manner
por: Xu, Feng, et al.
Publicado: (2020)

De mi país : descripciones, relatos y artículos de costumbres /
por: Unamuno, Miguel de, 1864-1936
Publicado: (1952)

MicroRNAs miR-27a and miR-143 Regulate Porcine Adipocyte Lipid Metabolism
por: Wang, Tao, et al.
Publicado: (2011)

miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila
por: Xiong, Xiao-Peng, et al.
Publicado: (2016)

MiR-34b-3 and miR-449a inhibit malignant progression of nasopharyngeal carcinoma by targeting lactate dehydrogenase A
por: Li, Huiling, et al.
Publicado: (2016)

HDL protects against myocardial ischemia reperfusion injury via miR-34b and miR-337 expression which requires STAT3
por: Pedretti, Sarah, et al.
Publicado: (2019)

STAT3 phosphorylation in central leptin resistance
por: Liu, Huimin, et al.
Publicado: (2021)

Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target
por: Liu, Shourong, et al.
Publicado: (2021)

New insights into adipocyte-specific leptin gene expression
por: Wrann, Christiane D., et al.
Publicado: (2012)

Statins decrease leptin expression in human white adipocytes
por: Singh, Prachi, et al.
Publicado: (2018)

Baicalin-modified polyethylenimine for miR-34a efficient and safe delivery
por: Wang, Yingying, et al.
Publicado: (2023)

miR-34a Blocks Osteoporosis and Bone Metastasis by Inhibiting Osteoclastogenesis and Tgif2
por: Krzeszinskia, Jing Y., et al.
Publicado: (2014)

miR-34 modulates wing polyphenism in planthopper
por: Ye, Xinhai, et al.
Publicado: (2019)

miR-26a-5p Regulates Adipocyte Differentiation via Directly Targeting ACSL3 in Adipocytes
por: Ding, Ning, et al.
Publicado: (2023)

miR-34c-5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer
por: Wei, Huali, et al.
Publicado: (2021)

MiR-34a and miR-34b/c have distinct effects on the suppression of lung adenocarcinomas
por: Kim, Jeong Seon, et al.
Publicado: (2019)

Analysis of the miR-34 family functions in breast cancer reveals annotation error of miR-34b
por: Engkvist, M. E., et al.
Publicado: (2017)

miR-34a Regulates Sperm Motility in Zebrafish
por: Guo, Wenjie, et al.
Publicado: (2017)

Cantos para conocer a mi país
por: Doblado del Rosario, Ibrahim, 1941-

LncRNA IMFNCR Promotes Intramuscular Adipocyte Differentiation by Sponging miR-128-3p and miR-27b-3p
por: Zhang, Meng, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_scc85rhm62tqqateegjhamnvsk