Cargando…

Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature

Natural killer (NK) cells, as members of the innate immune system, and natural killer T (NKT) cells, bridging innate and adaptive immunity, play a prominent role in chronic inflammatory diseases and cancerogenesis, yet have scarcely been examined in oral diseases. Therefore, systematic research on t...

Descripción completa

Detalles Bibliográficos
Autores principales: Seidel, Andreas, Seidel, Corinna L., Weider, Matthias, Junker, Rüdiger, Gölz, Lina, Schmetzer, Helga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767411/
https://www.ncbi.nlm.nih.gov/pubmed/33371393
http://dx.doi.org/10.3390/ijms21249766
_version_ 1783628952326111232
author Seidel, Andreas
Seidel, Corinna L.
Weider, Matthias
Junker, Rüdiger
Gölz, Lina
Schmetzer, Helga
author_facet Seidel, Andreas
Seidel, Corinna L.
Weider, Matthias
Junker, Rüdiger
Gölz, Lina
Schmetzer, Helga
author_sort Seidel, Andreas
collection PubMed
description Natural killer (NK) cells, as members of the innate immune system, and natural killer T (NKT) cells, bridging innate and adaptive immunity, play a prominent role in chronic inflammatory diseases and cancerogenesis, yet have scarcely been examined in oral diseases. Therefore, systematic research on the latest literature focusing on NK/NKT cell-mediated mechanisms in periodontal disease, including the time period 1988–2020, was carried out in MEDLINE (PubMed) using a predetermined search strategy, with a final selection of 25 studies. The results showed that NK cells tend to have rather proinflammatory influences via cytokine production, cytotoxic effects, dendritic-cell-crosstalk, and autoimmune reactions, while contrarily, NKT cell-mediated mechanisms were proinflammatory and immunoregulatory, ranging from protective effects via B-cell-regulation, specific antibody production, and the suppression of autoimmunity to destructive effects via cytokine production, dendritic-cell-crosstalk, and T-/B-cell interactions. Since NK cells seem to have a proinflammatory role in periodontitis, further research should focus on the proinflammatory and immunoregulatory properties of NKT cells in order to create, in addition to antibacterial strategies in dental inflammatory disease, novel anti-inflammatory therapeutic approaches modulating host immunity towards dental health.
format Online
Article
Text
id pubmed-7767411
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77674112020-12-28 Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature Seidel, Andreas Seidel, Corinna L. Weider, Matthias Junker, Rüdiger Gölz, Lina Schmetzer, Helga Int J Mol Sci Review Natural killer (NK) cells, as members of the innate immune system, and natural killer T (NKT) cells, bridging innate and adaptive immunity, play a prominent role in chronic inflammatory diseases and cancerogenesis, yet have scarcely been examined in oral diseases. Therefore, systematic research on the latest literature focusing on NK/NKT cell-mediated mechanisms in periodontal disease, including the time period 1988–2020, was carried out in MEDLINE (PubMed) using a predetermined search strategy, with a final selection of 25 studies. The results showed that NK cells tend to have rather proinflammatory influences via cytokine production, cytotoxic effects, dendritic-cell-crosstalk, and autoimmune reactions, while contrarily, NKT cell-mediated mechanisms were proinflammatory and immunoregulatory, ranging from protective effects via B-cell-regulation, specific antibody production, and the suppression of autoimmunity to destructive effects via cytokine production, dendritic-cell-crosstalk, and T-/B-cell interactions. Since NK cells seem to have a proinflammatory role in periodontitis, further research should focus on the proinflammatory and immunoregulatory properties of NKT cells in order to create, in addition to antibacterial strategies in dental inflammatory disease, novel anti-inflammatory therapeutic approaches modulating host immunity towards dental health. MDPI 2020-12-21 /pmc/articles/PMC7767411/ /pubmed/33371393 http://dx.doi.org/10.3390/ijms21249766 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Seidel, Andreas
Seidel, Corinna L.
Weider, Matthias
Junker, Rüdiger
Gölz, Lina
Schmetzer, Helga
Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature
title Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature
title_full Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature
title_fullStr Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature
title_full_unstemmed Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature
title_short Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature
title_sort influence of natural killer cells and natural killer t cells on periodontal disease: a systematic review of the current literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767411/
https://www.ncbi.nlm.nih.gov/pubmed/33371393
http://dx.doi.org/10.3390/ijms21249766
work_keys_str_mv AT seidelandreas influenceofnaturalkillercellsandnaturalkillertcellsonperiodontaldiseaseasystematicreviewofthecurrentliterature
AT seidelcorinnal influenceofnaturalkillercellsandnaturalkillertcellsonperiodontaldiseaseasystematicreviewofthecurrentliterature
AT weidermatthias influenceofnaturalkillercellsandnaturalkillertcellsonperiodontaldiseaseasystematicreviewofthecurrentliterature
AT junkerrudiger influenceofnaturalkillercellsandnaturalkillertcellsonperiodontaldiseaseasystematicreviewofthecurrentliterature
AT golzlina influenceofnaturalkillercellsandnaturalkillertcellsonperiodontaldiseaseasystematicreviewofthecurrentliterature
AT schmetzerhelga influenceofnaturalkillercellsandnaturalkillertcellsonperiodontaldiseaseasystematicreviewofthecurrentliterature