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Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan

This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery scho...

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Autores principales: Mizuki, Masaru, Tsukahara, Teruomi, Oda, Hirotsugu, Tanaka, Miyuki, Yamauchi, Koji, Abe, Fumiaki, Nomiyama, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767418/
https://www.ncbi.nlm.nih.gov/pubmed/33371454
http://dx.doi.org/10.3390/ijerph17249582
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author Mizuki, Masaru
Tsukahara, Teruomi
Oda, Hirotsugu
Tanaka, Miyuki
Yamauchi, Koji
Abe, Fumiaki
Nomiyama, Tetsuo
author_facet Mizuki, Masaru
Tsukahara, Teruomi
Oda, Hirotsugu
Tanaka, Miyuki
Yamauchi, Koji
Abe, Fumiaki
Nomiyama, Tetsuo
author_sort Mizuki, Masaru
collection PubMed
description This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19–6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women.
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spelling pubmed-77674182020-12-28 Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan Mizuki, Masaru Tsukahara, Teruomi Oda, Hirotsugu Tanaka, Miyuki Yamauchi, Koji Abe, Fumiaki Nomiyama, Tetsuo Int J Environ Res Public Health Article This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19–6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women. MDPI 2020-12-21 2020-12 /pmc/articles/PMC7767418/ /pubmed/33371454 http://dx.doi.org/10.3390/ijerph17249582 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mizuki, Masaru
Tsukahara, Teruomi
Oda, Hirotsugu
Tanaka, Miyuki
Yamauchi, Koji
Abe, Fumiaki
Nomiyama, Tetsuo
Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan
title Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan
title_full Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan
title_fullStr Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan
title_full_unstemmed Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan
title_short Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan
title_sort effects of lactoferrin on prevention of acute gastrointestinal symptoms in winter: a randomized, double-blinded, placebo-controlled trial for staff of kindergartens and nursery schools in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767418/
https://www.ncbi.nlm.nih.gov/pubmed/33371454
http://dx.doi.org/10.3390/ijerph17249582
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