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(Ascorb)ing Pb Neurotoxicity in the Developing Brain
Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant n...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767447/ https://www.ncbi.nlm.nih.gov/pubmed/33371438 http://dx.doi.org/10.3390/antiox9121311 |
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author | Ahmad, Faraz Liu, Ping |
author_facet | Ahmad, Faraz Liu, Ping |
author_sort | Ahmad, Faraz |
collection | PubMed |
description | Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies. |
format | Online Article Text |
id | pubmed-7767447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77674472020-12-28 (Ascorb)ing Pb Neurotoxicity in the Developing Brain Ahmad, Faraz Liu, Ping Antioxidants (Basel) Review Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies. MDPI 2020-12-21 /pmc/articles/PMC7767447/ /pubmed/33371438 http://dx.doi.org/10.3390/antiox9121311 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ahmad, Faraz Liu, Ping (Ascorb)ing Pb Neurotoxicity in the Developing Brain |
title | (Ascorb)ing Pb Neurotoxicity in the Developing Brain |
title_full | (Ascorb)ing Pb Neurotoxicity in the Developing Brain |
title_fullStr | (Ascorb)ing Pb Neurotoxicity in the Developing Brain |
title_full_unstemmed | (Ascorb)ing Pb Neurotoxicity in the Developing Brain |
title_short | (Ascorb)ing Pb Neurotoxicity in the Developing Brain |
title_sort | (ascorb)ing pb neurotoxicity in the developing brain |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767447/ https://www.ncbi.nlm.nih.gov/pubmed/33371438 http://dx.doi.org/10.3390/antiox9121311 |
work_keys_str_mv | AT ahmadfaraz ascorbingpbneurotoxicityinthedevelopingbrain AT liuping ascorbingpbneurotoxicityinthedevelopingbrain |