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Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State

Damage to the tissue and the ruining of functions characterize autoimmune syndromes. This review centers around leaky gut syndromes and how they stimulate autoimmune pathogenesis. Lymphoid tissue commonly associated with the gut, together with the neuroendocrine network, collaborates with the intest...

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Autores principales: Paray, Bilal Ahmad, Albeshr, Mohammed Fahad, Jan, Arif Tasleem, Rather, Irfan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767453/
https://www.ncbi.nlm.nih.gov/pubmed/33371435
http://dx.doi.org/10.3390/ijms21249770
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author Paray, Bilal Ahmad
Albeshr, Mohammed Fahad
Jan, Arif Tasleem
Rather, Irfan A.
author_facet Paray, Bilal Ahmad
Albeshr, Mohammed Fahad
Jan, Arif Tasleem
Rather, Irfan A.
author_sort Paray, Bilal Ahmad
collection PubMed
description Damage to the tissue and the ruining of functions characterize autoimmune syndromes. This review centers around leaky gut syndromes and how they stimulate autoimmune pathogenesis. Lymphoid tissue commonly associated with the gut, together with the neuroendocrine network, collaborates with the intestinal epithelial wall, with its paracellular tight junctions, to maintain the balance, tolerance, and resistance to foreign/neo-antigens. The physiological regulator of paracellular tight junctions plays a vital role in transferring macromolecules across the intestinal barrier and thereby maintains immune response equilibrium. A new paradigm has explained the intricacies of disease development and proposed that the processes can be prevented if the interaction between the genetic factor and environmental causes is barred by re-instituting the intestinal wall function. The latest clinical evidence and animal models reinforce this current thought and offer the basis for innovative methodologies to thwart and treat autoimmune syndromes.
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spelling pubmed-77674532020-12-28 Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State Paray, Bilal Ahmad Albeshr, Mohammed Fahad Jan, Arif Tasleem Rather, Irfan A. Int J Mol Sci Review Damage to the tissue and the ruining of functions characterize autoimmune syndromes. This review centers around leaky gut syndromes and how they stimulate autoimmune pathogenesis. Lymphoid tissue commonly associated with the gut, together with the neuroendocrine network, collaborates with the intestinal epithelial wall, with its paracellular tight junctions, to maintain the balance, tolerance, and resistance to foreign/neo-antigens. The physiological regulator of paracellular tight junctions plays a vital role in transferring macromolecules across the intestinal barrier and thereby maintains immune response equilibrium. A new paradigm has explained the intricacies of disease development and proposed that the processes can be prevented if the interaction between the genetic factor and environmental causes is barred by re-instituting the intestinal wall function. The latest clinical evidence and animal models reinforce this current thought and offer the basis for innovative methodologies to thwart and treat autoimmune syndromes. MDPI 2020-12-21 /pmc/articles/PMC7767453/ /pubmed/33371435 http://dx.doi.org/10.3390/ijms21249770 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paray, Bilal Ahmad
Albeshr, Mohammed Fahad
Jan, Arif Tasleem
Rather, Irfan A.
Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State
title Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State
title_full Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State
title_fullStr Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State
title_full_unstemmed Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State
title_short Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State
title_sort leaky gut and autoimmunity: an intricate balance in individuals health and the diseased state
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767453/
https://www.ncbi.nlm.nih.gov/pubmed/33371435
http://dx.doi.org/10.3390/ijms21249770
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