Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3β-β-Catenin and XIAP-Survivin Pathways

SIMPLE SUMMARY: CCT is a chaperonin that participates in folding intracellular proteins. We found that endogenously high expression of the subunit CCT-β is associated with a poorer chemotherapy response in clinical cancer patients. Using two cancer cell lines with higher CCT-β levels, a triple-negat...

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Detalles Bibliográficos
Autores principales: Chang, Yun-Xun, Lin, Yuan-Feng, Chen, Chi-Long, Huang, Ming-Shyan, Hsiao, Michael, Liang, Po-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767469/
https://www.ncbi.nlm.nih.gov/pubmed/33371405
http://dx.doi.org/10.3390/cancers12123865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767469/
https://www.ncbi.nlm.nih.gov/pubmed/33371405
http://dx.doi.org/10.3390/cancers12123865

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