The Antimalarial Compound Atovaquone Inhibits Zika and Dengue Virus Infection by Blocking E Protein-Mediated Membrane Fusion

Flaviviruses bear class II fusion proteins as their envelope (E) proteins. Here, we describe the development of an in vitro quantitative mosquito-cell-based membrane-fusion assay for the E protein using dual split proteins (DSPs). The assay does not involve the use of live viruses and allows the ana...

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Detalles Bibliográficos
Autores principales: Yamamoto, Mizuki, Ichinohe, Takeshi, Watanabe, Aya, Kobayashi, Ayako, Zhang, Rui, Song, Jiping, Kawaguchi, Yasushi, Matsuda, Zene, Inoue, Jun-ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767512/
https://www.ncbi.nlm.nih.gov/pubmed/33371476
http://dx.doi.org/10.3390/v12121475

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