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Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals
BACKGROUND: Metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) drives tumorigenesis of various human cancers. However, the association between MALAT1 variants and gastric cancer (GC) risk is unknown. We performed a case‐control study to evaluate the possible association between rs619586...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767557/ https://www.ncbi.nlm.nih.gov/pubmed/33135867 http://dx.doi.org/10.1002/mgg3.1541 |
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author | Hong, Jang Hee Jin, Eun‐Heui Chang, In Ae Kang, Hyojin Lee, Sang‐Il Sung, Jae Kyu |
author_facet | Hong, Jang Hee Jin, Eun‐Heui Chang, In Ae Kang, Hyojin Lee, Sang‐Il Sung, Jae Kyu |
author_sort | Hong, Jang Hee |
collection | PubMed |
description | BACKGROUND: Metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) drives tumorigenesis of various human cancers. However, the association between MALAT1 variants and gastric cancer (GC) risk is unknown. We performed a case‐control study to evaluate the possible association between rs619586 and rs3200401 SNPs in MALAT and GC risk. METHODS: Samples from 458 patients with GC and 381 controls were genotyped using the TaqMan genotyping assay. RESULTS: In stratified analyses, we observed that rs3200401 CT in the codominant model and CT+TT in the dominant model were associated with increased GC risk in male patients (CT: odds ratio [OR] = 1.81, 95% confidence interval [CI] = 1.09–3.01, p = 0.022; CT+TT: OR = 1.74, 95% CI = 1.07–2.83, p = 0.026), and the differentiated (CT: OR =1.79, 95% CI = 1.18–2.73, p = 0.007; CT+TT: OR = 1.76, 95% CI = 1.17–2.64, p = 0.007), and intestinal (CT: OR = 1.67, 95% CI = 1.11–2.49, p = 0.013; CT+TT: OR = 1.68, 95% CI = 1.14–2.47, p = 0.009) GC subgroups. CONCLUSION: MALAT1 rs3200401 increases GC susceptibility and might affect GC development. Further studies are needed to validate our results in large populations and different ethnic groups. |
format | Online Article Text |
id | pubmed-7767557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77675572020-12-28 Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals Hong, Jang Hee Jin, Eun‐Heui Chang, In Ae Kang, Hyojin Lee, Sang‐Il Sung, Jae Kyu Mol Genet Genomic Med Original Articles BACKGROUND: Metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) drives tumorigenesis of various human cancers. However, the association between MALAT1 variants and gastric cancer (GC) risk is unknown. We performed a case‐control study to evaluate the possible association between rs619586 and rs3200401 SNPs in MALAT and GC risk. METHODS: Samples from 458 patients with GC and 381 controls were genotyped using the TaqMan genotyping assay. RESULTS: In stratified analyses, we observed that rs3200401 CT in the codominant model and CT+TT in the dominant model were associated with increased GC risk in male patients (CT: odds ratio [OR] = 1.81, 95% confidence interval [CI] = 1.09–3.01, p = 0.022; CT+TT: OR = 1.74, 95% CI = 1.07–2.83, p = 0.026), and the differentiated (CT: OR =1.79, 95% CI = 1.18–2.73, p = 0.007; CT+TT: OR = 1.76, 95% CI = 1.17–2.64, p = 0.007), and intestinal (CT: OR = 1.67, 95% CI = 1.11–2.49, p = 0.013; CT+TT: OR = 1.68, 95% CI = 1.14–2.47, p = 0.009) GC subgroups. CONCLUSION: MALAT1 rs3200401 increases GC susceptibility and might affect GC development. Further studies are needed to validate our results in large populations and different ethnic groups. John Wiley and Sons Inc. 2020-11-02 /pmc/articles/PMC7767557/ /pubmed/33135867 http://dx.doi.org/10.1002/mgg3.1541 Text en © 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Hong, Jang Hee Jin, Eun‐Heui Chang, In Ae Kang, Hyojin Lee, Sang‐Il Sung, Jae Kyu Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals |
title | Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals |
title_full | Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals |
title_fullStr | Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals |
title_full_unstemmed | Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals |
title_short | Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals |
title_sort | association of long noncoding rna malat1 polymorphisms with gastric cancer risk in korean individuals |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767557/ https://www.ncbi.nlm.nih.gov/pubmed/33135867 http://dx.doi.org/10.1002/mgg3.1541 |
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