Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice

Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as TNFalpha. We aimed to test a hypothesis that TTP in bone marrow (BM) cells regulates atherogenesis by modulating inflammation an...

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Detalles Bibliográficos
Autores principales: Saaoud, Fatma, Wang, Junfeng, Iwanowycz, Stephen, Wang, Yuzhen, Altomare, Diego, Shao, Ying, Liu, Jianguo, Blackshear, Perry J., Lessner, Susan M., Murphy, E. Angela, Wang, Hong, Yang, Xiaofeng, Fan, Daping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Articles from the Special Issue on Redox Signalling and Cardiovascular Disease; Edited by Christopher Kevil and Yabing Chen
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767740/
https://www.ncbi.nlm.nih.gov/pubmed/32591281
http://dx.doi.org/10.1016/j.redox.2020.101609

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