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ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes

Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases, inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress, regulate metabolic pathways and initiate proliferation, inflammation and cell death responses remain poorly characterized. I...

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Autores principales: Sun, Yu, Lu, Yifan, Saredy, Jason, Wang, Xianwei, Drummer IV, Charles, Shao, Ying, Saaoud, Fatma, Xu, Keman, Liu, Ming, Yang, William Y., Jiang, Xiaohua, Wang, Hong, Yang, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767745/
https://www.ncbi.nlm.nih.gov/pubmed/32950427
http://dx.doi.org/10.1016/j.redox.2020.101696
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author Sun, Yu
Lu, Yifan
Saredy, Jason
Wang, Xianwei
Drummer IV, Charles
Shao, Ying
Saaoud, Fatma
Xu, Keman
Liu, Ming
Yang, William Y.
Jiang, Xiaohua
Wang, Hong
Yang, Xiaofeng
author_facet Sun, Yu
Lu, Yifan
Saredy, Jason
Wang, Xianwei
Drummer IV, Charles
Shao, Ying
Saaoud, Fatma
Xu, Keman
Liu, Ming
Yang, William Y.
Jiang, Xiaohua
Wang, Hong
Yang, Xiaofeng
author_sort Sun, Yu
collection PubMed
description Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases, inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress, regulate metabolic pathways and initiate proliferation, inflammation and cell death responses remain poorly characterized. In this analytic review, we concluded that: 1) Based on different features and functions, eleven types of ROS can be classified into seven functional groups: metabolic stress-sensing, chemical connecting, organelle communication, stress branch-out, inflammasome-activating, dual functions and triple functions ROS. 2) Among the ROS generation systems, mitochondria consume the most amount of oxygen; and nine types of ROS are generated; thus, mitochondrial ROS systems serve as the central hub for connecting ROS with inflammasome activation, trained immunity and immunometabolic pathways. 3) Increased nuclear ROS production significantly promotes cell death in comparison to that in other organelles. Nuclear ROS systems serve as a convergent hub and decision-makers to connect unbearable and alarming metabolic stresses to inflammation and cell death. 4) Balanced ROS levels indicate physiological homeostasis of various metabolic processes in subcellular organelles and cytosol, while imbalanced ROS levels present alarms for pathological organelle stresses in metabolic processes. Based on these analyses, we propose a working model that ROS systems are a new integrated network for sensing homeostasis and alarming stress in metabolic processes in various subcellular organelles. Our model provides novel insights on the roles of the ROS systems in bridging metabolic stress to inflammation, cell death and tumorigenesis; and provide novel therapeutic targets for treating those diseases. (Word count: 246).
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spelling pubmed-77677452020-12-29 ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes Sun, Yu Lu, Yifan Saredy, Jason Wang, Xianwei Drummer IV, Charles Shao, Ying Saaoud, Fatma Xu, Keman Liu, Ming Yang, William Y. Jiang, Xiaohua Wang, Hong Yang, Xiaofeng Redox Biol Review Article Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases, inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress, regulate metabolic pathways and initiate proliferation, inflammation and cell death responses remain poorly characterized. In this analytic review, we concluded that: 1) Based on different features and functions, eleven types of ROS can be classified into seven functional groups: metabolic stress-sensing, chemical connecting, organelle communication, stress branch-out, inflammasome-activating, dual functions and triple functions ROS. 2) Among the ROS generation systems, mitochondria consume the most amount of oxygen; and nine types of ROS are generated; thus, mitochondrial ROS systems serve as the central hub for connecting ROS with inflammasome activation, trained immunity and immunometabolic pathways. 3) Increased nuclear ROS production significantly promotes cell death in comparison to that in other organelles. Nuclear ROS systems serve as a convergent hub and decision-makers to connect unbearable and alarming metabolic stresses to inflammation and cell death. 4) Balanced ROS levels indicate physiological homeostasis of various metabolic processes in subcellular organelles and cytosol, while imbalanced ROS levels present alarms for pathological organelle stresses in metabolic processes. Based on these analyses, we propose a working model that ROS systems are a new integrated network for sensing homeostasis and alarming stress in metabolic processes in various subcellular organelles. Our model provides novel insights on the roles of the ROS systems in bridging metabolic stress to inflammation, cell death and tumorigenesis; and provide novel therapeutic targets for treating those diseases. (Word count: 246). Elsevier 2020-08-27 /pmc/articles/PMC7767745/ /pubmed/32950427 http://dx.doi.org/10.1016/j.redox.2020.101696 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Sun, Yu
Lu, Yifan
Saredy, Jason
Wang, Xianwei
Drummer IV, Charles
Shao, Ying
Saaoud, Fatma
Xu, Keman
Liu, Ming
Yang, William Y.
Jiang, Xiaohua
Wang, Hong
Yang, Xiaofeng
ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
title ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
title_full ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
title_fullStr ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
title_full_unstemmed ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
title_short ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
title_sort ros systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767745/
https://www.ncbi.nlm.nih.gov/pubmed/32950427
http://dx.doi.org/10.1016/j.redox.2020.101696
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