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Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis
Accumulation of senescent cells has a causative role in the pathology of age-related disorders including atherosclerosis (AS) and cardiovascular diseases (CVDs). However, the concept of senescence is now drastically changing, and the new concept of senescence-associated reprogramming/stemness has em...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767754/ https://www.ncbi.nlm.nih.gov/pubmed/32863187 http://dx.doi.org/10.1016/j.redox.2020.101614 |
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author | Dominic, Abishai Banerjee, Priyanka Hamilton, Dale J. Le, Nhat-Tu Abe, Jun-ichi |
author_facet | Dominic, Abishai Banerjee, Priyanka Hamilton, Dale J. Le, Nhat-Tu Abe, Jun-ichi |
author_sort | Dominic, Abishai |
collection | PubMed |
description | Accumulation of senescent cells has a causative role in the pathology of age-related disorders including atherosclerosis (AS) and cardiovascular diseases (CVDs). However, the concept of senescence is now drastically changing, and the new concept of senescence-associated reprogramming/stemness has emerged, suggesting that senescence is not merely related to “cell cycle arrest” or halting various cellular functions. It is well known that disturbed flow (D-flow) accelerates pre-mature aging and plays a significant role in the development of AS. We will discuss in this review that pre-mature aging induced by D-flow is not comparable to time-dependent aging, particularly with a focus on the possible involvement of senescence-associated secretory phenotype (SASP) in senescence-associated reprogramming/stemness, or increasing cell numbers. We will also present our outlook of nicotinamide adenine dinucleotides (NAD)(+) deficiency-induced mitochondrial reactive oxygen species (mtROS) in evoking SASP by activating DNA damage response (DDR). MtROS plays a key role in developing cross-talk between nuclear-mitochondria, SASP, and ultimately atherosclerosis formation. Although senescence induced by time and various stress factors is a classical concept, we wish that the readers will see the undergoing Copernican-like change in this concept, as well as to recognize the significant contrast between pre-mature aging induced by D-flow and time-dependent aging. |
format | Online Article Text |
id | pubmed-7767754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-77677542020-12-29 Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis Dominic, Abishai Banerjee, Priyanka Hamilton, Dale J. Le, Nhat-Tu Abe, Jun-ichi Redox Biol Review Article Accumulation of senescent cells has a causative role in the pathology of age-related disorders including atherosclerosis (AS) and cardiovascular diseases (CVDs). However, the concept of senescence is now drastically changing, and the new concept of senescence-associated reprogramming/stemness has emerged, suggesting that senescence is not merely related to “cell cycle arrest” or halting various cellular functions. It is well known that disturbed flow (D-flow) accelerates pre-mature aging and plays a significant role in the development of AS. We will discuss in this review that pre-mature aging induced by D-flow is not comparable to time-dependent aging, particularly with a focus on the possible involvement of senescence-associated secretory phenotype (SASP) in senescence-associated reprogramming/stemness, or increasing cell numbers. We will also present our outlook of nicotinamide adenine dinucleotides (NAD)(+) deficiency-induced mitochondrial reactive oxygen species (mtROS) in evoking SASP by activating DNA damage response (DDR). MtROS plays a key role in developing cross-talk between nuclear-mitochondria, SASP, and ultimately atherosclerosis formation. Although senescence induced by time and various stress factors is a classical concept, we wish that the readers will see the undergoing Copernican-like change in this concept, as well as to recognize the significant contrast between pre-mature aging induced by D-flow and time-dependent aging. Elsevier 2020-06-24 /pmc/articles/PMC7767754/ /pubmed/32863187 http://dx.doi.org/10.1016/j.redox.2020.101614 Text en © 2020 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Dominic, Abishai Banerjee, Priyanka Hamilton, Dale J. Le, Nhat-Tu Abe, Jun-ichi Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis |
title | Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis |
title_full | Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis |
title_fullStr | Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis |
title_full_unstemmed | Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis |
title_short | Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis |
title_sort | time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767754/ https://www.ncbi.nlm.nih.gov/pubmed/32863187 http://dx.doi.org/10.1016/j.redox.2020.101614 |
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