Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration

The retinal pigment epithelium (RPE) is the primary site of injury in non-neovascular age-related macular degeneration or dry AMD. Polymorphisms in genes that regulate complement activation and cholesterol metabolism are strongly associated with AMD, but the biology underlying disease-associated var...

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Detalles Bibliográficos
Autores principales: Tan, Li Xuan, Germer, Colin J., La Cunza, Nilsa, Lakkaraju, Aparna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767764/
https://www.ncbi.nlm.nih.gov/pubmed/33162377
http://dx.doi.org/10.1016/j.redox.2020.101781

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