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Sex-Related Differences in Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure

The coexistence of atrial fibrillation and heart failure significantly increases the risk of all-cause mortality and heart failure hospitalizations. Sex-related differences in all patients undergoing atrial fibrillation catheter ablation include the referral of fewer women for catheter ablation (15–...

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Detalles Bibliográficos
Autores principales: Chibber, Tamanna, Baranchuk, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767820/
https://www.ncbi.nlm.nih.gov/pubmed/33381530
http://dx.doi.org/10.3389/fcvm.2020.614031
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author Chibber, Tamanna
Baranchuk, Adrian
author_facet Chibber, Tamanna
Baranchuk, Adrian
author_sort Chibber, Tamanna
collection PubMed
description The coexistence of atrial fibrillation and heart failure significantly increases the risk of all-cause mortality and heart failure hospitalizations. Sex-related differences in all patients undergoing atrial fibrillation catheter ablation include the referral of fewer women for catheter ablation (15–25%), older age of women at ablation, and higher risk of post-ablation recurrence of atrial fibrillation. We searched the existing literature for sex-related differences in patients undergoing atrial fibrillation catheter ablation with a focus on heart failure. Randomized controlled trials assessing atrial fibrillation catheter ablation in patients with heart failure have demonstrated a significant reduction in all-cause mortality and heart failure hospitalizations. Within the eight existing randomized controlled trials on heart failure with reduced ejection fraction, women composed a small proportion of the study population. Only two studies (CASTLE-AF and AATAC-HF) specifically assessed the effect of gender on outcome and showed no difference in post-ablation outcomes. Registry data-based studies assessing sex-related differences in atrial fibrillation catheter ablation in heart failure reveal that women are half as likely as men to undergo ablation. Conflicting data exist on the interaction of gender and heart failure as they may affect peri-ablation and post-ablation long-term outcomes such as atrial fibrillation recurrence or heart failure hospitalizations. In conclusion, existing studies provide insight into the gender-based differences in patients undergoing catheter ablation for atrial fibrillation as it pertains to heart failure. Further prospective studies with higher proportions of female participants are required to accurately determine gender-based differences in this population.
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spelling pubmed-77678202020-12-29 Sex-Related Differences in Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure Chibber, Tamanna Baranchuk, Adrian Front Cardiovasc Med Cardiovascular Medicine The coexistence of atrial fibrillation and heart failure significantly increases the risk of all-cause mortality and heart failure hospitalizations. Sex-related differences in all patients undergoing atrial fibrillation catheter ablation include the referral of fewer women for catheter ablation (15–25%), older age of women at ablation, and higher risk of post-ablation recurrence of atrial fibrillation. We searched the existing literature for sex-related differences in patients undergoing atrial fibrillation catheter ablation with a focus on heart failure. Randomized controlled trials assessing atrial fibrillation catheter ablation in patients with heart failure have demonstrated a significant reduction in all-cause mortality and heart failure hospitalizations. Within the eight existing randomized controlled trials on heart failure with reduced ejection fraction, women composed a small proportion of the study population. Only two studies (CASTLE-AF and AATAC-HF) specifically assessed the effect of gender on outcome and showed no difference in post-ablation outcomes. Registry data-based studies assessing sex-related differences in atrial fibrillation catheter ablation in heart failure reveal that women are half as likely as men to undergo ablation. Conflicting data exist on the interaction of gender and heart failure as they may affect peri-ablation and post-ablation long-term outcomes such as atrial fibrillation recurrence or heart failure hospitalizations. In conclusion, existing studies provide insight into the gender-based differences in patients undergoing catheter ablation for atrial fibrillation as it pertains to heart failure. Further prospective studies with higher proportions of female participants are required to accurately determine gender-based differences in this population. Frontiers Media S.A. 2020-12-14 /pmc/articles/PMC7767820/ /pubmed/33381530 http://dx.doi.org/10.3389/fcvm.2020.614031 Text en Copyright © 2020 Chibber and Baranchuk. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Chibber, Tamanna
Baranchuk, Adrian
Sex-Related Differences in Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure
title Sex-Related Differences in Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure
title_full Sex-Related Differences in Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure
title_fullStr Sex-Related Differences in Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure
title_full_unstemmed Sex-Related Differences in Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure
title_short Sex-Related Differences in Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure
title_sort sex-related differences in catheter ablation for patients with atrial fibrillation and heart failure
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767820/
https://www.ncbi.nlm.nih.gov/pubmed/33381530
http://dx.doi.org/10.3389/fcvm.2020.614031
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