MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β(1)-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration

Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the tar...

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Detalles Bibliográficos
Autores principales: Zondler, Lisa, Herich, Sebastian, Kotte, Petra, Körner, Katharina, Schneider-Hohendorf, Tilman, Wiendl, Heinz, Schwab, Nicholas, Zarbock, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767877/
https://www.ncbi.nlm.nih.gov/pubmed/33381120
http://dx.doi.org/10.3389/fimmu.2020.599936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767877/
https://www.ncbi.nlm.nih.gov/pubmed/33381120
http://dx.doi.org/10.3389/fimmu.2020.599936

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