Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation

In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuplo...

Descripción completa

Detalles Bibliográficos
Autores principales: Moufarrej, Mira N., Wong, Ronald J., Shaw, Gary M., Stevenson, David K., Quake, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767905/
https://www.ncbi.nlm.nih.gov/pubmed/33381480
http://dx.doi.org/10.3389/fped.2020.605219
_version_ 1783629065083682816
author Moufarrej, Mira N.
Wong, Ronald J.
Shaw, Gary M.
Stevenson, David K.
Quake, Stephen R.
author_facet Moufarrej, Mira N.
Wong, Ronald J.
Shaw, Gary M.
Stevenson, David K.
Quake, Stephen R.
author_sort Moufarrej, Mira N.
collection PubMed
description In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RNA levels can correspond with tissue-specific gene expression and provide a snapshot of prenatal health across gestation. Here, we review the physiologic origins of cfRNA and its novel applications and corresponding challenges to monitor fetal and maternal health and predict pregnancy-related complications.
format Online
Article
Text
id pubmed-7767905
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-77679052020-12-29 Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation Moufarrej, Mira N. Wong, Ronald J. Shaw, Gary M. Stevenson, David K. Quake, Stephen R. Front Pediatr Pediatrics In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RNA levels can correspond with tissue-specific gene expression and provide a snapshot of prenatal health across gestation. Here, we review the physiologic origins of cfRNA and its novel applications and corresponding challenges to monitor fetal and maternal health and predict pregnancy-related complications. Frontiers Media S.A. 2020-12-14 /pmc/articles/PMC7767905/ /pubmed/33381480 http://dx.doi.org/10.3389/fped.2020.605219 Text en Copyright © 2020 Moufarrej, Wong, Shaw, Stevenson and Quake. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Moufarrej, Mira N.
Wong, Ronald J.
Shaw, Gary M.
Stevenson, David K.
Quake, Stephen R.
Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_full Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_fullStr Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_full_unstemmed Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_short Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_sort investigating pregnancy and its complications using circulating cell-free rna in women's blood during gestation
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767905/
https://www.ncbi.nlm.nih.gov/pubmed/33381480
http://dx.doi.org/10.3389/fped.2020.605219
work_keys_str_mv AT moufarrejmiran investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation
AT wongronaldj investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation
AT shawgarym investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation
AT stevensondavidk investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation
AT quakestephenr investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation

Ejemplares similares