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Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study)
This is a prospective observational cohort study aiming to include 4000 patients with stages I to III colon cancer treated at 35 specialist institutions in Japan, South Korea, Germany, Russia, Lithuania and Taiwan. The anatomical distribution of lymph nodes and feeding arteries are investigated usin...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767979/ https://www.ncbi.nlm.nih.gov/pubmed/33215206 http://dx.doi.org/10.1093/jjco/hyaa115 |
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author | Shiozawa, Manabu Ueno, Hideki Shiomi, Akio Kim, Nan Kyu Kim, Jin Cheon Tsarkov, Petr Grützmann, Robert Dulskas, Audrius Liang, Jin-Tung Samalavičius, Narimantas West, Nick Sugihara, Kenichi |
author_facet | Shiozawa, Manabu Ueno, Hideki Shiomi, Akio Kim, Nan Kyu Kim, Jin Cheon Tsarkov, Petr Grützmann, Robert Dulskas, Audrius Liang, Jin-Tung Samalavičius, Narimantas West, Nick Sugihara, Kenichi |
author_sort | Shiozawa, Manabu |
collection | PubMed |
description | This is a prospective observational cohort study aiming to include 4000 patients with stages I to III colon cancer treated at 35 specialist institutions in Japan, South Korea, Germany, Russia, Lithuania and Taiwan. The anatomical distribution of lymph nodes and feeding arteries are investigated using surgical specimens according to pre-specified categorizing methods using intraoperative anatomical markings. Primary analyses are performed to identify the general principles of metastatic lymph node distribution in terms of its relation to the location of the primary tumor and feeding arteries. Secondary analyses will be used to estimate prognostic outcomes according to bowel resection length and central radicality and will be used to evaluate the quality of resected surgical specimens. Through in-depth lymph node mapping, standardized criteria for the definite area of ‘regional’ lymph node resection in routine surgical procedures can be identified, which is expected to contribute to international standardization in colon cancer surgery (ClinicalTrials.gov NCT02938481). |
format | Online Article Text |
id | pubmed-7767979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77679792020-12-31 Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study) Shiozawa, Manabu Ueno, Hideki Shiomi, Akio Kim, Nan Kyu Kim, Jin Cheon Tsarkov, Petr Grützmann, Robert Dulskas, Audrius Liang, Jin-Tung Samalavičius, Narimantas West, Nick Sugihara, Kenichi Jpn J Clin Oncol Clinical Trial Note This is a prospective observational cohort study aiming to include 4000 patients with stages I to III colon cancer treated at 35 specialist institutions in Japan, South Korea, Germany, Russia, Lithuania and Taiwan. The anatomical distribution of lymph nodes and feeding arteries are investigated using surgical specimens according to pre-specified categorizing methods using intraoperative anatomical markings. Primary analyses are performed to identify the general principles of metastatic lymph node distribution in terms of its relation to the location of the primary tumor and feeding arteries. Secondary analyses will be used to estimate prognostic outcomes according to bowel resection length and central radicality and will be used to evaluate the quality of resected surgical specimens. Through in-depth lymph node mapping, standardized criteria for the definite area of ‘regional’ lymph node resection in routine surgical procedures can be identified, which is expected to contribute to international standardization in colon cancer surgery (ClinicalTrials.gov NCT02938481). Oxford University Press 2020-11-20 /pmc/articles/PMC7767979/ /pubmed/33215206 http://dx.doi.org/10.1093/jjco/hyaa115 Text en © The Author(s) 2020. Published by Oxford University Press. The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Clinical Trial Note Shiozawa, Manabu Ueno, Hideki Shiomi, Akio Kim, Nan Kyu Kim, Jin Cheon Tsarkov, Petr Grützmann, Robert Dulskas, Audrius Liang, Jin-Tung Samalavičius, Narimantas West, Nick Sugihara, Kenichi Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study) |
title | Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study) |
title_full | Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study) |
title_fullStr | Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study) |
title_full_unstemmed | Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study) |
title_short | Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study) |
title_sort | study protocol for an international prospective observational cohort study for optimal bowel resection extent and central radicality for colon cancer (t-rex study) |
topic | Clinical Trial Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767979/ https://www.ncbi.nlm.nih.gov/pubmed/33215206 http://dx.doi.org/10.1093/jjco/hyaa115 |
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