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Modulation of Gut Microbiota and Oxidative Status by β-Carotene in Late Pregnant Sows

Recent evidences suggest that gut microbiota plays an important role in regulating physiological and metabolic activities of pregnant sows, and β-carotene has a potentially positive effect on reproduction, but the impact of β-carotene on gut microbiota in pregnant sows remains unknown. This study ai...

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Autores principales: Yuan, Xupeng, Yan, Jiahao, Hu, Ruizhi, Li, Yanli, Wang, Ying, Chen, Hui, Hou, De-Xing, He, Jianhua, Wu, Shusong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768031/
https://www.ncbi.nlm.nih.gov/pubmed/33381515
http://dx.doi.org/10.3389/fnut.2020.612875
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author Yuan, Xupeng
Yan, Jiahao
Hu, Ruizhi
Li, Yanli
Wang, Ying
Chen, Hui
Hou, De-Xing
He, Jianhua
Wu, Shusong
author_facet Yuan, Xupeng
Yan, Jiahao
Hu, Ruizhi
Li, Yanli
Wang, Ying
Chen, Hui
Hou, De-Xing
He, Jianhua
Wu, Shusong
author_sort Yuan, Xupeng
collection PubMed
description Recent evidences suggest that gut microbiota plays an important role in regulating physiological and metabolic activities of pregnant sows, and β-carotene has a potentially positive effect on reproduction, but the impact of β-carotene on gut microbiota in pregnant sows remains unknown. This study aimed to explore the effect and mechanisms of β-carotene on the reproductive performance of sows from the aspect of gut microbiota. A total of 48 hybrid pregnant sows (Landrace × Yorkshire) with similar parity were randomly allocated into three groups (n = 16) and fed with a basal diet or a diet containing 30 or 90 mg/kg of β-carotene from day 90 of gestation until parturition. Dietary supplementation of 30 or 90 mg/kg β-carotene increased the number of live birth to 11.82 ± 1.54 and 12.29 ± 2.09, respectively, while the control group was 11.00 ± 1.41 (P = 0.201). Moreover, β-carotene increased significantly the serum nitric oxide (NO) level and glutathione peroxidase (GSH-Px) activity (P < 0.05). Characterization of fecal microbiota revealed that 90 mg/kg β-carotene increased the diversity of the gut flora (P < 0.05). In particular, β-carotene decreased the relative abundance of Firmicutes including Lachnospiraceae AC2044 group, Lachnospiraceae NK4B4 group and Ruminococcaceae UCG-008, but enriched Proteobacteria including Bilophila and Sutterella, and Actinobacteria including Corynebacterium and Corynebacterium 1 which are related to NO synthesis. These data demonstrated that dietary supplementation of β-carotene may increase antioxidant enzyme activity and NO, an important vasodilator to promote the neonatal blood circulation, through regulating gut microbiota in sows.
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spelling pubmed-77680312020-12-29 Modulation of Gut Microbiota and Oxidative Status by β-Carotene in Late Pregnant Sows Yuan, Xupeng Yan, Jiahao Hu, Ruizhi Li, Yanli Wang, Ying Chen, Hui Hou, De-Xing He, Jianhua Wu, Shusong Front Nutr Nutrition Recent evidences suggest that gut microbiota plays an important role in regulating physiological and metabolic activities of pregnant sows, and β-carotene has a potentially positive effect on reproduction, but the impact of β-carotene on gut microbiota in pregnant sows remains unknown. This study aimed to explore the effect and mechanisms of β-carotene on the reproductive performance of sows from the aspect of gut microbiota. A total of 48 hybrid pregnant sows (Landrace × Yorkshire) with similar parity were randomly allocated into three groups (n = 16) and fed with a basal diet or a diet containing 30 or 90 mg/kg of β-carotene from day 90 of gestation until parturition. Dietary supplementation of 30 or 90 mg/kg β-carotene increased the number of live birth to 11.82 ± 1.54 and 12.29 ± 2.09, respectively, while the control group was 11.00 ± 1.41 (P = 0.201). Moreover, β-carotene increased significantly the serum nitric oxide (NO) level and glutathione peroxidase (GSH-Px) activity (P < 0.05). Characterization of fecal microbiota revealed that 90 mg/kg β-carotene increased the diversity of the gut flora (P < 0.05). In particular, β-carotene decreased the relative abundance of Firmicutes including Lachnospiraceae AC2044 group, Lachnospiraceae NK4B4 group and Ruminococcaceae UCG-008, but enriched Proteobacteria including Bilophila and Sutterella, and Actinobacteria including Corynebacterium and Corynebacterium 1 which are related to NO synthesis. These data demonstrated that dietary supplementation of β-carotene may increase antioxidant enzyme activity and NO, an important vasodilator to promote the neonatal blood circulation, through regulating gut microbiota in sows. Frontiers Media S.A. 2020-12-14 /pmc/articles/PMC7768031/ /pubmed/33381515 http://dx.doi.org/10.3389/fnut.2020.612875 Text en Copyright © 2020 Yuan, Yan, Hu, Li, Wang, Chen, Hou, He and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Yuan, Xupeng
Yan, Jiahao
Hu, Ruizhi
Li, Yanli
Wang, Ying
Chen, Hui
Hou, De-Xing
He, Jianhua
Wu, Shusong
Modulation of Gut Microbiota and Oxidative Status by β-Carotene in Late Pregnant Sows
title Modulation of Gut Microbiota and Oxidative Status by β-Carotene in Late Pregnant Sows
title_full Modulation of Gut Microbiota and Oxidative Status by β-Carotene in Late Pregnant Sows
title_fullStr Modulation of Gut Microbiota and Oxidative Status by β-Carotene in Late Pregnant Sows
title_full_unstemmed Modulation of Gut Microbiota and Oxidative Status by β-Carotene in Late Pregnant Sows
title_short Modulation of Gut Microbiota and Oxidative Status by β-Carotene in Late Pregnant Sows
title_sort modulation of gut microbiota and oxidative status by β-carotene in late pregnant sows
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768031/
https://www.ncbi.nlm.nih.gov/pubmed/33381515
http://dx.doi.org/10.3389/fnut.2020.612875
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