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The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice

Inflammation has been proposed to play a causal role in chemobrain which—if true—would represent an opportunity to repurpose existing anti-inflammatory drugs for the prevention and treatment of chemobrain. Here, we show that the chemoagent paclitaxel induces memory impairment and anhedonia in mice w...

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Autores principales: Chang, Aeson, Chung, Ni-Chun, Lawther, Adam J., Ziegler, Alexandra I., Shackleford, David M., Sloan, Erica K., Walker, Adam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768078/
https://www.ncbi.nlm.nih.gov/pubmed/33381448
http://dx.doi.org/10.3389/fonc.2020.564965
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author Chang, Aeson
Chung, Ni-Chun
Lawther, Adam J.
Ziegler, Alexandra I.
Shackleford, David M.
Sloan, Erica K.
Walker, Adam K.
author_facet Chang, Aeson
Chung, Ni-Chun
Lawther, Adam J.
Ziegler, Alexandra I.
Shackleford, David M.
Sloan, Erica K.
Walker, Adam K.
author_sort Chang, Aeson
collection PubMed
description Inflammation has been proposed to play a causal role in chemobrain which—if true—would represent an opportunity to repurpose existing anti-inflammatory drugs for the prevention and treatment of chemobrain. Here, we show that the chemoagent paclitaxel induces memory impairment and anhedonia in mice within 24 h of treatment cessation, but inflammation is not present until 2 weeks after treatment. We find no evidence of brain inflammation as measured by cytokine analysis at any time point. Furthermore, treating with aspirin to block inflammation did not affect paclitaxel-induced memory impairment. These findings suggest that inflammation may not be responsible for memory impairment induced by paclitaxel. These results contrast with recent findings of a causal role for inflammation in cancer-induced memory deficits in mice that were prevented by treatment with oral aspirin, suggesting that cognitive impairment in cancer patients undergoing treatment may arise from multiple convergent mechanisms.
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spelling pubmed-77680782020-12-29 The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice Chang, Aeson Chung, Ni-Chun Lawther, Adam J. Ziegler, Alexandra I. Shackleford, David M. Sloan, Erica K. Walker, Adam K. Front Oncol Oncology Inflammation has been proposed to play a causal role in chemobrain which—if true—would represent an opportunity to repurpose existing anti-inflammatory drugs for the prevention and treatment of chemobrain. Here, we show that the chemoagent paclitaxel induces memory impairment and anhedonia in mice within 24 h of treatment cessation, but inflammation is not present until 2 weeks after treatment. We find no evidence of brain inflammation as measured by cytokine analysis at any time point. Furthermore, treating with aspirin to block inflammation did not affect paclitaxel-induced memory impairment. These findings suggest that inflammation may not be responsible for memory impairment induced by paclitaxel. These results contrast with recent findings of a causal role for inflammation in cancer-induced memory deficits in mice that were prevented by treatment with oral aspirin, suggesting that cognitive impairment in cancer patients undergoing treatment may arise from multiple convergent mechanisms. Frontiers Media S.A. 2020-12-14 /pmc/articles/PMC7768078/ /pubmed/33381448 http://dx.doi.org/10.3389/fonc.2020.564965 Text en Copyright © 2020 Chang, Chung, Lawther, Ziegler, Shackleford, Sloan and Walker http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chang, Aeson
Chung, Ni-Chun
Lawther, Adam J.
Ziegler, Alexandra I.
Shackleford, David M.
Sloan, Erica K.
Walker, Adam K.
The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice
title The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice
title_full The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice
title_fullStr The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice
title_full_unstemmed The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice
title_short The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice
title_sort anti-inflammatory drug aspirin does not protect against chemotherapy-induced memory impairment by paclitaxel in mice
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768078/
https://www.ncbi.nlm.nih.gov/pubmed/33381448
http://dx.doi.org/10.3389/fonc.2020.564965
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