Co-evolution of mutagenic genome editors and vertebrate adaptive immunity

The adaptive immune systems of all vertebrates rely on self-DNA mutating enzymes to assemble their antigen receptors in lymphocytes of their two principal lineages. In jawed vertebrates, the RAG1/2 recombinase directs V(D)J recombination of B cell and T cell receptor genes, whereas the activation-in...

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Detalles Bibliográficos
Autores principales: Trancoso, Inês, Morimoto, Ryo, Boehm, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768089/
https://www.ncbi.nlm.nih.gov/pubmed/32353821
http://dx.doi.org/10.1016/j.coi.2020.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768089/
https://www.ncbi.nlm.nih.gov/pubmed/32353821
http://dx.doi.org/10.1016/j.coi.2020.03.001

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