The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies

Synovial sarcoma (SyS) is an aggressive mesenchymal malignancy invariably associated with the chromosomal translocation t(X:18; p11:q11), which results in the in-frame fusion of the BAF complex gene SS18 to one of three SSX genes. Fusion of SS18 to SSX generates an aberrant transcriptional regulator...

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Detalles Bibliográficos
Autores principales: Boulay, Gaylor, Cironi, Luisa, Garcia, Sara P, Rengarajan, Shruthi, Xing, Yu-Hang, Lee, Lukuo, Awad, Mary E, Naigles, Beverly, Iyer, Sowmya, Broye, Liliane C, Keskin, Tugba, Cauderay, Alexandra, Fusco, Carlo, Letovanec, Igor, Chebib, Ivan, Nielsen, Petur Gunnalugur, Tercier, Stéphane, Cherix, Stéphane, Nguyen-Ngoc, Tu, Cote, Gregory, Choy, Edwin, Provero, Paolo, Suvà, Mario L, Rivera, Miguel N, Stamenkovic, Ivan, Riggi, Nicolò
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768195/
https://www.ncbi.nlm.nih.gov/pubmed/33361335
http://dx.doi.org/10.26508/lsa.202000808

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