The Interaction of Munc18-1 Helix 11 and 12 with the Central Region of the VAMP2 SNARE Motif Is Essential for SNARE Templating and Synaptic Transmission

Sec1/Munc18 proteins play a key role in initiating the assembly of N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes, the molecular fusion machinery. Employing comparative structure modeling, site specific crosslinking by single amino acid substitutions with the photoac...

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Detalles Bibliográficos
Autores principales: André, Timon, Classen, Jessica, Brenner, Philipp, Betts, Matthew J., Dörr, Bernhard, Kreye, Susanne, Zuidinga, Birte, Meijer, Marieke, Russell, Robert B., Verhage, Matthijs, Söllner, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768276/
https://www.ncbi.nlm.nih.gov/pubmed/33055194
http://dx.doi.org/10.1523/ENEURO.0278-20.2020

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