Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma
Although the cases of endometrial carcinoma (EC) is gradually increasing across the world, its etiology and pathogenesis remain unknown. The present study is the first to define the role and biological function of circRNA hsa_circ_0075960 in the development and progression of EC. We first determined...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768316/ https://www.ncbi.nlm.nih.gov/pubmed/33356989 http://dx.doi.org/10.1177/1533033820983079 |
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author | Wu, Bo Ren, Ailing Tian, Ying Huang, Ruizhen |
author_facet | Wu, Bo Ren, Ailing Tian, Ying Huang, Ruizhen |
author_sort | Wu, Bo |
collection | PubMed |
description | Although the cases of endometrial carcinoma (EC) is gradually increasing across the world, its etiology and pathogenesis remain unknown. The present study is the first to define the role and biological function of circRNA hsa_circ_0075960 in the development and progression of EC. We first determined that hsa_circ_0075960 is aberrantly expressed in EC cells. Then, we uncovered that the downregulation of hsa_circ_0075960 suppressed cell proliferation and promoted cell apoptosis of EC cells, suggesting that hsa_circ_0075960 could inhibit the progression of EC in vitro. In addition, we identified that miR-361-3p was the direct target of hsa_circ_0075960. Further analysis revealed that hsa_circ_0075960 affected the development of EC via sponging miR-361-3p. Interestingly, we verified that the level of SH2B1 was controlled by the downregulation of hsa_circ_0075960 and that the negative effect caused by hsa_circ_0075960 could be reversed via miR-361-3p inhibition. Our cumulative results revealed that the novel tumor regulator hsa_circ_0075960 functioned as a sponge for miR-361-3p/SH2B1 in EC cells and regulated the progression of EC through the modulation of miR-361-3p. |
format | Online Article Text |
id | pubmed-7768316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-77683162021-01-21 Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma Wu, Bo Ren, Ailing Tian, Ying Huang, Ruizhen Technol Cancer Res Treat Original Article Although the cases of endometrial carcinoma (EC) is gradually increasing across the world, its etiology and pathogenesis remain unknown. The present study is the first to define the role and biological function of circRNA hsa_circ_0075960 in the development and progression of EC. We first determined that hsa_circ_0075960 is aberrantly expressed in EC cells. Then, we uncovered that the downregulation of hsa_circ_0075960 suppressed cell proliferation and promoted cell apoptosis of EC cells, suggesting that hsa_circ_0075960 could inhibit the progression of EC in vitro. In addition, we identified that miR-361-3p was the direct target of hsa_circ_0075960. Further analysis revealed that hsa_circ_0075960 affected the development of EC via sponging miR-361-3p. Interestingly, we verified that the level of SH2B1 was controlled by the downregulation of hsa_circ_0075960 and that the negative effect caused by hsa_circ_0075960 could be reversed via miR-361-3p inhibition. Our cumulative results revealed that the novel tumor regulator hsa_circ_0075960 functioned as a sponge for miR-361-3p/SH2B1 in EC cells and regulated the progression of EC through the modulation of miR-361-3p. SAGE Publications 2020-12-24 /pmc/articles/PMC7768316/ /pubmed/33356989 http://dx.doi.org/10.1177/1533033820983079 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Wu, Bo Ren, Ailing Tian, Ying Huang, Ruizhen Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma |
title | Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in
Endometrial Carcinoma |
title_full | Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in
Endometrial Carcinoma |
title_fullStr | Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in
Endometrial Carcinoma |
title_full_unstemmed | Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in
Endometrial Carcinoma |
title_short | Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in
Endometrial Carcinoma |
title_sort | hsa_circ_0075960 serves as a sponge for mir-361-3p/sh2b1 in
endometrial carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768316/ https://www.ncbi.nlm.nih.gov/pubmed/33356989 http://dx.doi.org/10.1177/1533033820983079 |
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