Multicenter, Randomized, Phase III Trial of Neoadjuvant Chemoradiation With Capecitabine and Irinotecan Guided by UGT1A1 Status in Patients With Locally Advanced Rectal Cancer

Differentiating the irinotecan dose on the basis of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotype improves the pathologic complete response (pCR) rate. In this study, we further investigated preoperative irinotecan combined with capecitabine-based chemoradiotherapy for locall...

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Detalles Bibliográficos
Autores principales: Zhu, Ji, Liu, Anwen, Sun, Xinchen, Liu, Luying, Zhu, Yaqun, Zhang, Tao, Jia, Jianhui, Tan, Shisheng, Wu, Junxin, Wang, Xin, Zhou, Juying, Yang, Jialin, Zhang, Chen, Zhang, Hongyan, Zhao, Yuanyuan, Cai, Gang, Zhang, Wei, Xia, Fan, Wan, Juefeng, Zhang, Hui, Shen, Lijun, Cai, SanJun, Zhang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2020
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768334/
https://www.ncbi.nlm.nih.gov/pubmed/33119477
http://dx.doi.org/10.1200/JCO.20.01932

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