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Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series

Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) is associated with relapsing multifocal skin and soft tissue infections (SSTI), necrotizing pneumonia (NP) and severe musculoskeletal infections. Epidemiology is underknown and underdiagnosis is likely. Recent travel abroad, case c...

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Autores principales: Prista-Leão, Beatriz, Abreu, Isabel, Duro, Raquel, Silva-Pinto, André, Ceia, Filipa, Andrade, Paulo, Sobrinho-Simões, Joana, Tavares, Margarida, Pereira, José Manuel, Santos, Lurdes, Sarmento, António
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768458/
https://www.ncbi.nlm.nih.gov/pubmed/33153134
http://dx.doi.org/10.3390/idr12030014
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author Prista-Leão, Beatriz
Abreu, Isabel
Duro, Raquel
Silva-Pinto, André
Ceia, Filipa
Andrade, Paulo
Sobrinho-Simões, Joana
Tavares, Margarida
Pereira, José Manuel
Santos, Lurdes
Sarmento, António
author_facet Prista-Leão, Beatriz
Abreu, Isabel
Duro, Raquel
Silva-Pinto, André
Ceia, Filipa
Andrade, Paulo
Sobrinho-Simões, Joana
Tavares, Margarida
Pereira, José Manuel
Santos, Lurdes
Sarmento, António
author_sort Prista-Leão, Beatriz
collection PubMed
description Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) is associated with relapsing multifocal skin and soft tissue infections (SSTI), necrotizing pneumonia (NP) and severe musculoskeletal infections. Epidemiology is underknown and underdiagnosis is likely. Recent travel abroad, case clustering and relapsing disease are often reported. We reviewed all cases of PVL-SA infection diagnosed at our center, and found 21 cases over a 43-month period. Most patients were adult males, had relevant travel history, reported recurrent disease and presented with SSTI. Etiologic diagnosis took up to five years; meanwhile, 42% of patients had antibiotic treatments. Draining procedures were required in 43% of patients and intensive care support in 19%. All patients recovered. Methicillin-resistance prevalence was 24%. Only 2/13 decolonized patients had posterior relapsing SSTI, both with likely infected contacts. PVL-SA infection’s severity and impact are clear, even in small case series as ours. Physician awareness and active PVL-gene search are crucial for an adequate management.
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spelling pubmed-77684582020-12-29 Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series Prista-Leão, Beatriz Abreu, Isabel Duro, Raquel Silva-Pinto, André Ceia, Filipa Andrade, Paulo Sobrinho-Simões, Joana Tavares, Margarida Pereira, José Manuel Santos, Lurdes Sarmento, António Infect Dis Rep Case Report Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) is associated with relapsing multifocal skin and soft tissue infections (SSTI), necrotizing pneumonia (NP) and severe musculoskeletal infections. Epidemiology is underknown and underdiagnosis is likely. Recent travel abroad, case clustering and relapsing disease are often reported. We reviewed all cases of PVL-SA infection diagnosed at our center, and found 21 cases over a 43-month period. Most patients were adult males, had relevant travel history, reported recurrent disease and presented with SSTI. Etiologic diagnosis took up to five years; meanwhile, 42% of patients had antibiotic treatments. Draining procedures were required in 43% of patients and intensive care support in 19%. All patients recovered. Methicillin-resistance prevalence was 24%. Only 2/13 decolonized patients had posterior relapsing SSTI, both with likely infected contacts. PVL-SA infection’s severity and impact are clear, even in small case series as ours. Physician awareness and active PVL-gene search are crucial for an adequate management. MDPI 2020-11-03 /pmc/articles/PMC7768458/ /pubmed/33153134 http://dx.doi.org/10.3390/idr12030014 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Prista-Leão, Beatriz
Abreu, Isabel
Duro, Raquel
Silva-Pinto, André
Ceia, Filipa
Andrade, Paulo
Sobrinho-Simões, Joana
Tavares, Margarida
Pereira, José Manuel
Santos, Lurdes
Sarmento, António
Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series
title Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series
title_full Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series
title_fullStr Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series
title_full_unstemmed Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series
title_short Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series
title_sort panton-valentine leukocidin-producing staphylococcus aureus infection: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768458/
https://www.ncbi.nlm.nih.gov/pubmed/33153134
http://dx.doi.org/10.3390/idr12030014
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