Cargando…
Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab
We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal i...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768469/ https://www.ncbi.nlm.nih.gov/pubmed/33291619 http://dx.doi.org/10.3390/pediatric12030029 |
_version_ | 1783629164022071296 |
---|---|
author | Niño-Taravilla, Carmen Espinosa-Vielma, Yazmín P. Otaola-Arca, Hugo Poli-Harlowe, Cecilia Tapia, Lorena I. Ortiz-Fritz, Paula |
author_facet | Niño-Taravilla, Carmen Espinosa-Vielma, Yazmín P. Otaola-Arca, Hugo Poli-Harlowe, Cecilia Tapia, Lorena I. Ortiz-Fritz, Paula |
author_sort | Niño-Taravilla, Carmen |
collection | PubMed |
description | We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal involvement characterized by inflammation of the wall of the bowel and pancreatitis. After treatment with Tocilizumab and corticoid therapy, he presented clinical improvement and normalization of inflammatory markers. PIMS-TS is a new disease developed in a small percentage of patients, so a high degree of suspicion is necessary to establish the diagnosis. Supportive care is of paramount importance. The use of Tocilizumab to control the inflammatory response is likely to be beneficial, but the best immunotherapeutic agent has not yet been established. Randomized clinical studies should be run to determine the best treatment. |
format | Online Article Text |
id | pubmed-7768469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77684692020-12-29 Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab Niño-Taravilla, Carmen Espinosa-Vielma, Yazmín P. Otaola-Arca, Hugo Poli-Harlowe, Cecilia Tapia, Lorena I. Ortiz-Fritz, Paula Pediatr Rep Case Report We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal involvement characterized by inflammation of the wall of the bowel and pancreatitis. After treatment with Tocilizumab and corticoid therapy, he presented clinical improvement and normalization of inflammatory markers. PIMS-TS is a new disease developed in a small percentage of patients, so a high degree of suspicion is necessary to establish the diagnosis. Supportive care is of paramount importance. The use of Tocilizumab to control the inflammatory response is likely to be beneficial, but the best immunotherapeutic agent has not yet been established. Randomized clinical studies should be run to determine the best treatment. MDPI 2020-12-04 /pmc/articles/PMC7768469/ /pubmed/33291619 http://dx.doi.org/10.3390/pediatric12030029 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Niño-Taravilla, Carmen Espinosa-Vielma, Yazmín P. Otaola-Arca, Hugo Poli-Harlowe, Cecilia Tapia, Lorena I. Ortiz-Fritz, Paula Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab |
title | Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab |
title_full | Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab |
title_fullStr | Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab |
title_full_unstemmed | Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab |
title_short | Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab |
title_sort | pediatric inflammatory multisystem syndrome temporally associated with sars-cov-2 treated with tocilizumab |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768469/ https://www.ncbi.nlm.nih.gov/pubmed/33291619 http://dx.doi.org/10.3390/pediatric12030029 |
work_keys_str_mv | AT ninotaravillacarmen pediatricinflammatorymultisystemsyndrometemporallyassociatedwithsarscov2treatedwithtocilizumab AT espinosavielmayazminp pediatricinflammatorymultisystemsyndrometemporallyassociatedwithsarscov2treatedwithtocilizumab AT otaolaarcahugo pediatricinflammatorymultisystemsyndrometemporallyassociatedwithsarscov2treatedwithtocilizumab AT poliharlowececilia pediatricinflammatorymultisystemsyndrometemporallyassociatedwithsarscov2treatedwithtocilizumab AT tapialorenai pediatricinflammatorymultisystemsyndrometemporallyassociatedwithsarscov2treatedwithtocilizumab AT ortizfritzpaula pediatricinflammatorymultisystemsyndrometemporallyassociatedwithsarscov2treatedwithtocilizumab |