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Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab

We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal i...

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Autores principales: Niño-Taravilla, Carmen, Espinosa-Vielma, Yazmín P., Otaola-Arca, Hugo, Poli-Harlowe, Cecilia, Tapia, Lorena I., Ortiz-Fritz, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768469/
https://www.ncbi.nlm.nih.gov/pubmed/33291619
http://dx.doi.org/10.3390/pediatric12030029
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author Niño-Taravilla, Carmen
Espinosa-Vielma, Yazmín P.
Otaola-Arca, Hugo
Poli-Harlowe, Cecilia
Tapia, Lorena I.
Ortiz-Fritz, Paula
author_facet Niño-Taravilla, Carmen
Espinosa-Vielma, Yazmín P.
Otaola-Arca, Hugo
Poli-Harlowe, Cecilia
Tapia, Lorena I.
Ortiz-Fritz, Paula
author_sort Niño-Taravilla, Carmen
collection PubMed
description We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal involvement characterized by inflammation of the wall of the bowel and pancreatitis. After treatment with Tocilizumab and corticoid therapy, he presented clinical improvement and normalization of inflammatory markers. PIMS-TS is a new disease developed in a small percentage of patients, so a high degree of suspicion is necessary to establish the diagnosis. Supportive care is of paramount importance. The use of Tocilizumab to control the inflammatory response is likely to be beneficial, but the best immunotherapeutic agent has not yet been established. Randomized clinical studies should be run to determine the best treatment.
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spelling pubmed-77684692020-12-29 Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab Niño-Taravilla, Carmen Espinosa-Vielma, Yazmín P. Otaola-Arca, Hugo Poli-Harlowe, Cecilia Tapia, Lorena I. Ortiz-Fritz, Paula Pediatr Rep Case Report We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal involvement characterized by inflammation of the wall of the bowel and pancreatitis. After treatment with Tocilizumab and corticoid therapy, he presented clinical improvement and normalization of inflammatory markers. PIMS-TS is a new disease developed in a small percentage of patients, so a high degree of suspicion is necessary to establish the diagnosis. Supportive care is of paramount importance. The use of Tocilizumab to control the inflammatory response is likely to be beneficial, but the best immunotherapeutic agent has not yet been established. Randomized clinical studies should be run to determine the best treatment. MDPI 2020-12-04 /pmc/articles/PMC7768469/ /pubmed/33291619 http://dx.doi.org/10.3390/pediatric12030029 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Niño-Taravilla, Carmen
Espinosa-Vielma, Yazmín P.
Otaola-Arca, Hugo
Poli-Harlowe, Cecilia
Tapia, Lorena I.
Ortiz-Fritz, Paula
Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab
title Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab
title_full Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab
title_fullStr Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab
title_full_unstemmed Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab
title_short Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab
title_sort pediatric inflammatory multisystem syndrome temporally associated with sars-cov-2 treated with tocilizumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768469/
https://www.ncbi.nlm.nih.gov/pubmed/33291619
http://dx.doi.org/10.3390/pediatric12030029
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